SML0668
Calhex 231 hydrochloride
≥98% (HPLC)
Synonym(s):
4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Estimated to ship onJuly 27, 2026fromMILWAUKEE | $167.00 |
25 mg | Estimated to ship onJuly 27, 2026fromMILWAUKEE | $454.00 |
About This Item
Empirical Formula (Hill Notation):
C25H27ClN2O · HCl
CAS Number:
Molecular Weight:
443.41
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
−20°C
Application
Calhex 231 hydrochloride has been used:
- as a calcium-sensing receptor (CaSR) antagonist: to test its impact on hearing in rats[1]
- to test its effect on blood pressure levels spontaneous hypertensive rats (SHRs)[2]
- to test its effect on acoustic response bias in zebrafish[3]
- in Caco-2 cells to test its effect on, overexpression of fibroblast growth factor-23 (FGF-23 )[4]
Biochem/physiol Actions
Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR.
Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR. Calhex 231 blocks calcium-induced accumulation of inositol phosphate with an IC50 of 0.36 μM.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥95% (HPLC) |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 15 mg/mL, clear | solubility DMSO: 10 mg/mL, clear | solubility DMSO: >10 mg/mL | solubility DMSO: ≥10 mg/mL |
| storage condition desiccated | storage condition - | storage condition desiccated | storage condition desiccated |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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