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SML2997

GHP-88309

≥98% (HPLC), paramyxovirus polymerase inhibitor, powder

Synonym(s):

2-Fluoro-6-(5-isoquinolinyl)benzamide; 2-Fluoro-6-(5-isoquinolyl)benzamide, GHP 88309, GHP88309

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$144.00
25 mg

Available to ship TODAYfromMILWAUKEE

$461.00

About This Item

Empirical Formula (Hill Notation):
C16H11FN2O
CAS Number:
Molecular Weight:
266.27
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$144.00


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Product Name

GHP-88309, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC1=C(C(N)=O)C(C2=C(C=CN=C3)C3=CC=C2)=CC=C1

InChI key

OLNVLPGIADWVKU-UHFFFAOYSA-N

Biochem/physiol Actions

GHP-88309 is an orally available non-nucleoside paramyxovirus polymerase inhibitor with broad-spectrum anti-paramyxoviral activity (EC50 in μM= 0.4/HPIV3-JS, 0.8/HPIV3-5F6, 2/SeV-F1R-eGF, 0.6/MeV/Alaska.USA 16.00, 0.4/CDV-5804p) and little cytoxicity (CC50 >20μM). GHP-88309 potently inhibits the replication of HPIV1 isolate 5F6 and HPIV3 isolates 10L3 & 9R4 in 3D-ALI-HBTEC human airway organoids (EC50 = 280,90, 105 nM, respectively) in 3D-ALI-HBTECs. HPIV3 and provides complete protection against lethal Sendai virus infection in mice (150 mg/kg bid. po. starting at time of infection or 48 hrs after), a murine surrogate model of human HPIV3 disease.
Orally available non-nucleoside paramyxovirus polymerase inhibitor with broad-spectrum anti-paramyxoviral activity in vitro and in vivo.

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This Item
SML3261SML3147SML0660
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

DMSO: 15 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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