Z-2108
ZytoLight® SPEC CCND1 Dual Color Break Apart Probe
green to orange, pkg of 0.05 mL, pkg of 0.2 mL
Synonym(s):
FISH, probe
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packaging
pkg of 0.05 mL, pkg of 0.2 mL, pkg of 20 tests, pkg of 5 tests
storage condition
protect from light
color
green to orange
application(s)
research use
storage temp.
2-8°C
General description
The ZytoLight® SPEC CCND1 Dual ColorBreak Apart Probe (PL65) is a probe for qualitative detection of translocations associated the human CCND1 gene at 11q13.3.
Application
It specifically assists in differentiating atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLPS) and dedifferentiated liposarcoma (DDLPS) by identifying CDK4 amplification, a crucial marker that distinguishes these tumors from other sarcomas.
Analysis Note
- With the use of appropriate filter sets, the hybridization signals of the probeappear green (proximal to the CCND1 breakpoint region) and orange(distal to the CCND1 breakpoint region).
- Normal situation: In interphases of normal cells or cells without atranslocation involving the CCND1 gene region, two green/orange fusionsignals appear
- Aberrant situation: One CCND1 gene region affected by a translocation isindicated by one separate green signal and one separate orange signal
- Overlapping signals may appear as yellow signals.
Legal Information
ZytoLight is a registered trademark of ZytoVision GmbH in Germany
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Carc. 2 - Repr. 1B - STOT RE 2 Oral
Target Organs
Blood
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
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