07-239

Anti-mGluR7-Antikörper

Upstate^®, from rabbit

• Synonym(e): Anti-GLUR7, Anti-MGLU7, Anti-MGLUR7, Anti-NEDSHBA, Anti-PPP1R87
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 19

Eigenschaften

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: purified antibody
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: rat
• manufacturer/tradename: Upstate^®
• technique(s): western blot: suitable
• isotype: IgG
• NCBI accession no.: NM_000831
• UniProt accession no.: Q14831
• shipped in: dry ice
• target post-translational modification: unmodified
• Gene Information: human ... GRM7(2917)

Beschreibung

General description

97 kDa

Metabotropic glutamate receptor 7 (UniProt: Q14831; also known as mGluR7) is encoded by the GRM7 (also known as GPRC1G, MGLUR7) gene (Gene ID: 2917) in human. GRM7 gene is mapped to human chromosome 3p26. L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. GRM7 belongs to Group III, and members of group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. mGluR7 is a multi-pass membrane protein and is synthesized with a signal peptide (aa 1-34), which is subsequently cleaved off to produce the mature protein (aa 35-915). mGluR7 is expressed in several parts of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. It is located in the presynaptic zone of the synaptic cleft of glutamatergic synapses. Five isoforms of mGluR7 have been described that are produced by alternative splicing. The gene coding MGLUR7 is associated with autism and also participates in schizophrenia and bipolar disorder. Dysregulation of mGluR7 has been implicated in several neuropsychiatric disorders, including anxiety, depression, and fragile X syndrome (FXS), where its modulation by allosteric agents like AMN082 has shown therapeutic potential. Studies suggest that drugs targeting mGluR7: mGluR7 agonists, antagonists, and allosteric modulators may play a role as promising agents for the treatment of central nervous system disorders. (Ref.: Li P., et al. (2024). Ageing Res Rev. 102;102554; Palazzo E., et al. (2016). Curr Neuropharmacol. 14(5); 504-513).

Immunogen

Peptid (C-NSPAAKKKYVSYNN), das den Aminosäuren 899–912 von humanem mGluR7 entspricht.

Application

Forschungs-Unterkategorie
Vesikeltransport

Neurodegenerative Erkrankungen

Forschungskategorie
Neurowissenschaft

Weisen Sie mGluR7 mit diesem Anti-mGluR7-Antikörper, der für den Gebrauch in WB validiert ist, nach.

Biochem/physiol Actions

mGluR7

Physical form

Format: Aufgereinigt

Protein-A-Chromatografie

Preparation Note

2 Jahre bei -20 °C

Analysis Note

Regelmäßig mittels Immunblot an einem mikrosomalen Rattenhirnpräparat beurteilt

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Sofern in unserem Katalog oder anderen Begleitdokumenten unserer Produkte nicht anders angegeben, sind unsere Produkte nur für Forschungszwecke vorgesehen und nicht für andere Zwecke zu verwenden, einschließlich, jedoch nicht beschränkt auf unautorisierte kommerzielle Verwendung, zur In-vitro-Diagnostik, für Ex-vivo- oder In-vivo-Therapiezwecke oder jegliche Art der Einnahme oder Anwendung bei Menschen oder Tieren.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 1