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124015

Akt Inhibitor IV

Name: Akt Inhibitor IV
Brand: MM

InSolution, ≥98%

Synonym(e):

InSolution Akt Inhibitor IV

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Über diesen Artikel

Empirische Formel (Hill-System):

C₃₁H₂₇IN₄S

Molekulargewicht:

614.54

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

liquid

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Technischer Dienst

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Eigenschaften

Quality Segment

100

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

shipped in

wet ice

storage temp.

2-8°C

Beschreibung

General description

A cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC₅₀ = 625 nM) and cell proliferation (IC₅₀<1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Akt

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 625 nM and <1.25 µM in blocking Akt-mediated FOXO1a nuclear export and cell proliferation, respectively, in 786-O cells

Packaging

Packaged under inert gas

Please refer to vial label for lot-specific concentration.

Physical form

A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124011) in DMSO.

Preparation Note

Following initial use, aliquot and refrigerate (4°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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Dieser Artikel	124011	124009	124008
Sigma-Aldrich 124015 Akt Inhibitor IV	Sigma-Aldrich 124011 Akt Inhibitor IV	Sigma-Aldrich 124009 Akt Inhibitor III	Sigma-Aldrich 124008 Akt Inhibitor II
description InSolution, ≥98%	description The Akt Inhibitor IV, also referenced under CAS 681281-88-9, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description The Akt Inhibitor III controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description The Akt Inhibitor II controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (NMR)	assay ≥98% (NMR)
form liquid	form solid	form solid	form solid
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C
storage condition desiccated (hygroscopic), OK to freeze, protect from light	storage condition desiccated (hygroscopic), OK to freeze, protect from light	storage condition OK to freeze	storage condition OK to freeze

Lagerklasse

10 - Combustible liquids

Was ist los?

WGK 2

Flammpunkt (°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

Flammpunkt (°C)

87 °C - closed cup - (Dimethylsulfoxide)

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Analysenzertifikate (COA)

Lot/Batch Number

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