178496

Apoptosis Activator VI, CD437/AHPN

The Apoptosis Activator VI, CD437/AHPN, also referenced under CAS 125316-60-1, modulates Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(e): Apoptosis Activator VI, CD437/AHPN, 6-(3-(1-Adamantyl)-4-hydroxyphenyl)-2-naphthalene carboxylic acid
• Empirische Formel (Hill-System): C₂₇H₂₆O₃
• CAS-Nummer: 125316-60-1
• Molekulargewicht: 398.49
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD03106506
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: DMSO: 39 mg/mL, ethanol: 39 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: Oc1c(cc(cc1)c5cc6c(cc(cc6)C(=O)O)cc5)C32CC4CC(C3)CC(C2)C4
• InChI: 1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)
• InChI key: LDGIHZJOIQSHPB-UHFFFAOYSA-N

Beschreibung

General description

A cell-permeable retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that CD437/AHPN effectively functions as an ER stress inducer.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 months at -20°C.

Other Notes

Watanabe, Y., et al. 2008. Biochem. Biophys. Res. Comm.366, 840.
Holmes, W.F., et al. 2004. J. Cell. Physiol.199, 317.
Zhao, X., and Spanjaard, R.A. 2003. J. Biomed. Sci.10, 44.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable