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178496

Apoptosis Activator VI, CD437/AHPN

Name: Apoptosis Activator VI, CD437/AHPN
Brand: MM

The Apoptosis Activator VI, CD437/AHPN, also referenced under CAS 125316-60-1, modulates Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(e):

Apoptosis Activator VI, CD437/AHPN, 6-(3-(1-Adamantyl)-4-hydroxyphenyl)-2-naphthalene carboxylic acid

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Über diesen Artikel

Empirische Formel (Hill-System):

C₂₇H₂₆O₃

CAS-Nummer:

125316-60-1

Molekulargewicht:

398.49

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD03106506

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Eigenschaften

Quality Segment

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 39 mg/mL, ethanol: 39 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Oc1c(cc(cc1)c5cc6c(cc(cc6)C(=O)O)cc5)C32CC4CC(C3)CC(C2)C4

InChI

1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)

InChI key

LDGIHZJOIQSHPB-UHFFFAOYSA-N

Beschreibung

General description

A cell-permeable retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that CD437/AHPN effectively functions as an ER stress inducer.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 months at -20°C.

Other Notes

Watanabe, Y., et al. 2008. Biochem. Biophys. Res. Comm.366, 840.
Holmes, W.F., et al. 2004. J. Cell. Physiol.199, 317.
Zhao, X., and Spanjaard, R.A. 2003. J. Biomed. Sci.10, 44.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

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Dieser Artikel	C5865	178493	178488
Sigma-Aldrich 178496 Apoptosis Activator VI, CD437/AHPN	Sigma-Aldrich C5865 CD437	Sigma-Aldrich 178493 Apoptosis Activator III, Embelin	Sigma-Aldrich 178488 Apoptose-Inhibitor
description The Apoptosis Activator VI, CD437/AHPN, also referenced under CAS 125316-60-1, modulates Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.	description ≥98% (HPLC), solid	description The Apoptosis Activator III, Embelin, also referenced under CAS 550-24-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.	description The Apoptosis Inhibitor, also referenced under CAS 54135-60-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
form solid	form solid	form solid	form solid
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay -	assay ≥95% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility ethanol: 39 mg/mL, DMSO: 39 mg/mL	solubility DMSO: >10 mg/mL, H₂O: insoluble	solubility methanol: 5 mg/mL, DMSO: 10 mg/mL	solubility DMSO: 100 mg/mL, ethanol: 20 mg/mL

Lagerklasse

11 - Combustible Solids

Was ist los?

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Lot/Batch Number

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