200499

Bexarotene

≥96% (HPLC), retinoid X receptor agonist, powder

• Synonym(e): Bexarotene, 4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid
• Empirische Formel (Hill-System): C₂₄H₂₈O₂
• CAS-Nummer: 153559-49-0
• Molekulargewicht: 348.48
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00932428
• Assay: ≥96% (HPLC)
• Form: powder
• Storage condition: OK to freeze, protect from light

Eigenschaften

• Produktname: Bexarotene, A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner.
• Quality Segment: 100
• assay: ≥96% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white to orange
• solubility: DMSO: 50 mg/mL, clear, colorless
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: OC(=O)c1ccc(cc1)C(=C)c2cc3c(cc2C)C(CCC3(C)C)(C)C
• InChI: 1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
• InChI key: NAVMQTYZDKMPEU-UHFFFAOYSA-N

Beschreibung

General description

A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner (25% reduction in 6 h and 50% reduction in 72 h). Causes a rapid reversal of cognitive, social, and olfactory deficts. Shown to progressively enhance the expression of ApoE and ATP-binding cassette transporters ABCA1 and ABCG1. Also stimulates the secretion of highly lapidated HDL particles in primary microglia and astrocytes. Does not affect the levels of Aβ proteases, insulin degrading enzyme, and neprilysin.

Biochem/physiol Actions

Cell permeable: yes

Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Cramer, P.E., et al. 2012. Science Exp.335, 1503.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable