422682

K _ir1.1 Inhibitor, VU591

The K_ir1.1 Inhibitor, VU591 controls the biological activity of K_ir1.1. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Synonym(e): K _ir1.1 Inhibitor, VU591
• Empirische Formel (Hill-System): C₁₆H₁₂N₆O₅
• CAS-Nummer: 1222810-74-3
• Molekulargewicht: 368.30
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: light gray
• solubility: DMSO: 100 mg/mL, clear, dark brown
• shipped in: ambient
• storage temp.: 2-8°C

Beschreibung

General description

A cell-permeable, benzoimidazole, renal outer medullary potassium channel (ROMK) blocker that selectively inhibits inward rectifier potassium channel, K_ir1.1 (IC₅₀ = 240 nM), in HEK-293 cells. At 10 µM, it displays no effect on Kir2.1, Kir2.3, Kir4.1, and Kir7.1, with 150-fold selectivity over K_ir6.2. In addition, it exhibits a modest off-target effect on the GABA_A receptor (IC₅₀ = 6.2 µM) among a panel of cardiac and central nervous system ion channels and receptors.

The K_ir1.1 Inhibitor, VU591 controls the biological activity of K_ir1.1. This small molecule/inhibitor is primarily used for Neuroscience applications.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Bhave, G., et al. 2011. Mol Pharmacol.79, 42.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable