5.08159

Salvinorin A

• Synonym(e): Salvinorin A, κ-opioid Receptor Agonist, Salvinorin A, Divinorin A
• Empirische Formel (Hill-System): C₂₃H₂₈O₈
• CAS-Nummer: 83729-01-5
• Molekulargewicht: 432.46
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD05664742
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Eigenschaften

• assay: ≥98% (HPLC)
• Quality Segment: 100
• form: solid
• potency: 4.3 nM K_i
• manufacturer/tradename: Calbiochem^®
• drug control: Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet
• storage condition: OK to freeze, protect from light
• color: white
• solubility: ethanol: 10 mM, DMSO: 50 mM
• storage temp.: −70°C
• SMILES string: [o]1cc(cc1)[C@H]2OC(=O)[C@H]3[C@@]([C@@H]4[C@]([C@@H](C[C@@H](C4=O)OC(=O)C)C(=O)OC)(CC3)C)(C2)C
• InChI: 1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1
• InChI key: OBSYBRPAKCASQB-AGQYDFLVSA-N

Beschreibung

General description

A highly potent and selective non-alkaloid positive allosteric modulator of Κ-opioid receptors (K_i = 4.3 nM and 16 nM for native and cloned κ-opioid receptors, respectively). Also acts as a D2DR partial agonist (K_i = 5-10 nM). Used in studies of addition.

Biochem/physiol Actions

Primary Target
k opioid receptor

Other Notes

Roth, B. et al., 2002. PNAS.99, 11934.
Valdés III., j., et al., 1984. J. Organic Chem.49, 4716.
Ortega, A., et al., 1982. J. of Chem. Society, Perkins Transactions I. 2505.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3