539610

PKC_ζ/ι Pseudosubstrate Inhibitor

The PKC_ζ/ι Pseudosubstrate Inhibitor controls the biological activity of PKC_ζ/ι. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(e): PKC_ζ/ι Pseudosubstrate Inhibitor, SIYRRGARRWRKL, Protein Kinase C _ζ/ι Pseudosubstrate Inhibitor, SIYRRGARRWRKL, Protein Kinase C_ζ/ι Pseudosubstrate Inhibitor
• Empirische Formel (Hill-System): C₇₆H₁₂₈N₃₀O₁₆
• Molekulargewicht: 1718.02
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: lyophilized
• Storage condition: OK to freeze, desiccated (hygroscopic)

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: lyophilized
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• solubility: glacial acetic acid: 2 mg/mL, water: 2 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Beschreibung

General description

A selective, reversible, and substrate competitive inhibitor of protein kinase C_ζ and protein kinase C_ι (PKC_ζ/ι) isozymes.

Non-cell-permeable protein kinase C_ζ and protein kinase C_ι pseudosubstrate sequence peptide that can be used as a selective, reversible, and substrate competitive inhibitor PKC_ζ/ι in in vitro kinase assays.

Biochem/physiol Actions

Cell permeable: no

Primary Target
PKCζ

Product does not compete with ATP.

Reversible: yes

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

H-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH

Sajan, M.P., et al. 1999. J. Biol. Chem.274, 30495.
Laudanna, C., et al. 1998. J. Biol. Chem.273, 30306.
Standaert, M.L., et al. 1997. J. Biol. Chem.272, 30075.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable