548000

1-Pyrrolidinecarbodithioic Acid, Ammonium Salt

Cell permeable. Inhibits the induction of NOS activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells.

• Synonym(e): 1-Pyrrolidinecarbodithioic Acid, Ammonium Salt, APDC, Ammonium Pyrrolidinedithiocarbamate, PDTC, NH₄
• Empirische Formel (Hill-System): C₅H₁₂N₂S₂
• CAS-Nummer: 5108-96-3
• Molekulargewicht: 164.29
• UNSPSC Code: 12352106
• NACRES: NA.77
• MDL number: MFCD00012720
• Assay: ≥98% (titration)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic)

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (titration)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: white
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [S-]C(=S)N1CCCC1.[N+H4]
• InChI: 1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
• InChI key: MDDIUTVUBYEEEM-UHFFFAOYSA-N

Beschreibung

General description

Cell permeable. Inhibits the induction of nitric oxide synthase activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells. Inhibits NF-κB activation and HIV replication in lymphocytes.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Induction of nitric oxide synthase activity in rat alveolar macrophages

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.







From Catalog:

Desc. Field- added "cell-permeable"

Other Notes

Tsai, J.C., et al. 1996. J. Biol. Chem.271, 3667.
Pan, Z., et al. 1995. J. Biol. Chem.270, 7787.
Bessho, R., et al. 1994. Biochem. Pharmacol.48, 1883.
Sherman, M.P., et al. 1993. Biochem. Biophys. Res. Commun.191, 1301.
Schreck, R., et al. 1992. J. Exp. Med.175, 1181.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable