This product is suitable for in vitro binding assays. It is advisable to consult peer-reviewed literature on in vitro binding assays between sialyl Lewis x and E-selectins specifically. Publications such as "Sialyl Lewisx Glycomimetics as E- and P-Selectin Antagonists Targeting Hyperinflammation," in ACS Med. Chem. Lett. (16)1, 64–71, indicate that catch bonds formed between selectins and sialyl Lewis x can affect binding affinity based on static versus dynamic environments. This effect may present challenges in accurately quantifying in vitro binding, depending on the nature of the binding assay. Therefore, in vivo studies might be important for a more accurate assessment of biological activity.
565950
Sialyl Lewis x, Sodium Salt
Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins.
Synonym(e):
Sialyl Lewis x, Sodium Salt, SLe x, Neu5Acα2,3Galβ1,4(Fucα1,3)GlcNAc, SLex, Neu5Acα2,3Galβ1,4(Fucα1,3)GlcNAc
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Über diesen Artikel
Empirische Formel (Hill-System):
C31H51N2NaO23
CAS-Nummer:
Molekulargewicht:
842.73
UNSPSC Code:
12352201
NACRES:
NA.79
MDL number:
Preise und Verfügbarkeit sind derzeit nicht verfügbar.
Technischer Dienst
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Unterstützung erhaltenQuality Segment
assay
≥95% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 2 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
N([C@H]1[C@@H](O[C@@](C[C@@H]1O)(O[C@@H]2[C@H]([C@@H](O[C@@H]([C@@H]2O)CO)O[C@@H]([C@H](O[C@@H]3O[C@H]([C@H]([C@H]([C@@H]3O)O)O)C)[C@@H](NC(=O)C)C=O)[C@H](O)CO)O)C(=O)O)[C@H](O)[C@H](O)CO)C(=O)C
InChI
1S/C31H52N2O23/c1-9-18(43)21(46)22(47)28(51-9)53-24(12(5-34)32-10(2)38)25(15(42)7-36)54-29-23(48)27(20(45)16(8-37)52-29)56-31(30(49)50)4-13(40)17(33-11(3)39)26(55-31)19(44)14(41)6-35/h5,9,12-29,35-37,40-48H,4,6-8H2,1-3H3,(H,32,38)(H,33,39)(H,49,50)/t9-,12-,13-,14+,15+,16+,17+,18+,19+,20-,21+,22-,23+,24+,25+,26+,27-,28-,29-,31-/m0/s1
InChI key
LAQPKDLYOBZWBT-NYLDSJSYSA-N
General description
Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins. SLex reduces injury following ischemia and reperfusion and immune complex-induced acute lung injury in animal models. In both of these models, SLex is presumed to act by blocking E-selectin-mediated neutrophil recruitment to sites of inflammation.
Other Notes
Seekamp, A., et al. 1994. Am. J. Pathol.144, 592.
Mulligan, M.S., et al. 1993. J. Exp. Med.178, 623.
Ichikawa, Y., et al. 1992. J. Am. Chem. Soc. 114, 9283.
Lasky, L.A. 1992. Science 258, 964.
Mulligan, M.S., et al. 1993. J. Exp. Med.178, 623.
Ichikawa, Y., et al. 1992. J. Am. Chem. Soc. 114, 9283.
Lasky, L.A. 1992. Science 258, 964.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Dieser Artikel | |||
|---|---|---|---|
| description Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins. | description - | description - | description clone 121SLE, purified immunoglobulin, buffered aqueous solution |
| assay ≥95% (TLC) | assay - | assay - | assay - |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| solubility water: 2 mg/mL | solubility - | solubility - | solubility - |
| form solid | form - | form - | form buffered aqueous solution |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| color white | color - | color - | color - |
Lagerklasse
11 - Combustible Solids
Was ist los?
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Is this product appropriate for an in vitro e-selectin binding assay?
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