8.53034

Boc-His(Trt)-OH

≥98.0% (HPLC), for peptide synthesis, Novabiochem^®

• Synonym(e): Boc-His(Trt)-OH, N-α-t.-Boc-N-im-trityl-L-histidine
• Empirische Formel (Hill-System): C₃₀H₃₁N₃O₄
• CAS-Nummer: 32926-43-5
• Molekulargewicht: 497.58
• UNSPSC Code: 12352209
• NACRES: NA.22
• MDL number: MFCD00153307

Eigenschaften

• Produktname: Boc-His(Trt)-OH, Novabiochem^®
• Quality Segment: 200
• product line: Novabiochem^®
• assay: ≥95.0% (acidimetric), ≥98% (TLC), ≥98.0% (HPLC)
• form: powder
• reaction suitability: reaction type: Boc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• mp: 130 °C (decomposition)
• application(s): peptide synthesis
• storage temp.: 15-25°C
• SMILES string: [n]4(cnc(c4)C[C@H](NC(=O)OC(C)(C)C)C(=O)O)C(c3ccccc3)(c2ccccc2)c1ccccc1
• InChI: 1S/C30H31N3O4/c1-29(2,3)37-28(36)32-26(27(34)35)19-25-20-33(21-31-25)30(22-13-7-4-8-14-22,23-15-9-5-10-16-23)24-17-11-6-12-18-24/h4-18,20-21,26H,19H2,1-3H3,(H,32,36)(H,34,35)/t26-/m0/s1
• InChI key: OYXZPXVCRAAKCM-SANMLTNESA-N

Beschreibung

General description

A protected histidine derivative for only the critical coupling step in Boc SPPS. After coupling the Boc- and Trt-groups are cleaved simultaneously by TFA.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS

Analysis Note

Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 95.0 %
Water (K. F.): ≤ 4.00 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Other Notes

Replaces: 04-12-0160

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable