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8.55140

Fmoc-PAL-Linker

Novabiochem®

Synonym(e):

Fmoc-PAL-Linker

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Größe/SKUVerfügbarkeitPreis
1 g
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€ 89,60
5 g
Warenkorb auf Verfügbarkeit prüfen
€ 384,00

Über diesen Artikel

Empirische Formel (Hill-System):
C29H31NO7
CAS-Nummer:
115109-65-4
Molekulargewicht:
505.56
MDL number:
MFCD00236731
UNSPSC Code:
12352209
NACRES:
NA.22

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Quality Segment

product line

Novabiochem®

form

solid

reaction suitability

reagent type: linker

manufacturer/tradename

Novabiochem®

mp

178-180 °C

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

2-8°C

SMILES string

N(Cc4c(cc(cc4OC)OCCCCC(=O)O)OC)C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C29H31NO7/c1-34-26-15-19(36-14-8-7-13-28(31)32)16-27(35-2)24(26)17-30-29(33)37-18-25-22-11-5-3-9-20(22)21-10-4-6-12-23(21)25/h3-6,9-12,15-16,25H,7-8,13-14,17-18H2,1-2H3,(H,30,33)(H,31,32)

InChI key

ATYUCXIJDKHOPX-UHFFFAOYSA-N

General description

Barany′s aminomethyl-dimethoxyphenoxyvaleric acid linker . The amino group of this linker can be easily acylated under standard coupling conditions. Following peptide assembly, treatment with 95% TFA containing scavengers releases the desired peptide amide. Studies have shown the acid sensitivity of this linker to be around twice that of the Rink amide linker. There is some evidence to suggest that PAL resins give greater yields in microwave assisted synthesis.

Associated Protocols and Technical Articles


Protocols for Loading of Peptide Synthesis Resins

Analysis Note

Color (visual): white to beige to grey
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(0811)): ≥ 98.0 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Lagerklasse

11 - Combustible Solids

Was ist los?

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Lot/Batch Number

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Questions

  1. In the General Description of the product Fmoc-PAL-Linker Catalog 8.55140 there are numbers for two references ([1] and [2]) but I can not either follow a link or see the references. Would it be possible to provide me the references? Thanks

    1 answer

    1. The references for the product Fmoc-PAL-Linker are as follows:

      (1) Gisin BF. 1973. The Preparation of Merrifield-Resins Through Total Esterification With Cesium Salts. Helv. Chim. Acta. 56(5): 1476-1482.
      (2) Atherton E., Logan CJ, Sheppard RC. Peptide synthesis, Part 2. Procedures for solid-phase synthesis using N(alpha)-fluorenylmethoxycarbonylamino-acids on polyamide supports. Synthesis of substance P and of acyl carrier protein 65-74 decapeptide. J. Chem. Soc., Perkin Trans. 1. (0): 538-546.

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