ABC337

Anti-BAFF receptor Antibody

from rabbit, purified by affinity chromatography

• Synonym(e): Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, BAFF-R, BLyS receptor 3, CD268
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC, WB
• Citations: -

Eigenschaften

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: rat, human, mouse
• technique(s): immunohistochemistry: suitable, western blot: suitable
• UniProt accession no.: Q96RJ3
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... TNFRSF13C(115650)

Beschreibung

General description

B-cell-activating factor receptor (BAFF receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) and BLyS receptor 3 (BR3), is a member of the TNF superfamily that regulate immune responses and induce apoptosis. BAFF receptor promotes the survival of mature B-cells and the B-cell response. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-jun N-terminal kinase. BAFF receptor is highly expressed in spleen and lymph node, with lower levels found in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. Mutations in BAFF receptor have been associated with immunodeficiency common variable type 4 (CVID4), also called BAFFR defect.

~22 kDa observed. Uniprot describes two isoforms at ~19 kDa Uncharacterized bands may appear in some lysates.

Immunogen

KLH-conjugated linear peptide corresponding to the C-terminus of human BAFF receptor.

Application

Detect B-cell-activating factor receptor using this rabbit polyclonal antibody, Anti-BAFF receptor Antibody validated for use in western blotting & IHC.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected BAFF receptor in human tonsil tissue.

Biochem/physiol Actions

This antibody recognizes the C-terminus of BAFF receptor.

Analysis Note

Control
Human, mouse, and rat spleen tissue lysates

Evaluated by Western Blotting in human, mouse, and rat spleen tissue lysates.

Western Blotting Analysis: 5 µg/mL of this antibody detected BAFF receptor in 15 µg of human, mouse, and rat spleen tissue lysates.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Sicherheitshinweise

• wgk: WGK 2
• Lagerklasse: 12 - Non Combustible Liquids