SCC138

LAMA-87 Human Chronic Myeloid Leukemia Cell Line

The LAMA-87 human chronic myeloid leukemia cell line is useful for studying the molecular regulation of pluripotent cell commitment and provide a useful tool for hematopoiesis studies.

• UNSPSC Code: 41106514
• NACRES: NA.28
• eCl@ss: 32160903

Eigenschaften

• application(s): cell analysis

Beschreibung

General description

The LAMA-87 human chronic myeloid leukemia cell line is an erythroeosinophilic cell line derived from LAMA-84 (2). LAMA-87 cells are positive for the BCR-ABL gene translocation (3) and express erythrocytic markers such as glycophorin A, as well as the CD33 granulomonocytic marker CD33, which distinguishes CML from other leukemias (2). When inoculated into non-treated athymic mice, LAMA-87 cells can differentiate to give rise to eosinomonocytic cells (2).

Source:
The LAMA-87 cell line was derived from LAMA-84 human chronic myeloid leukemia cells inoculated into estrone-treated athymic mice (2). The parent LAMA-84 cell line was isolated from leukemia of a 29-year-old female patient (3).

Research Category:
Cancer

Biochem/physiol Actions

Human, Cancer Cells

Packaging

≥1X10⁶ cells/vial

Preparation Note

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Other Notes

Subject to local law, this product is intended to be sold for internal in vitro research use only subject to terms and conditions found here: www.sigmaaldrich.com/restrictedcelluse. This product may not be: re-engineered or copied; used to make derivatives, modifications or functional equivalents; used to obtain patents or other IP claiming use of the product; used to develop, test, or manufacturer a commercial product; used as a component in a commercial product; resold or licensed; used in any clinical applications or trials; or used in humans. A license or limited commercial use agreement is required for use by any for-profit entity, use in services, and use in sponsored academic research. For information regarding any such use, please contact licensing@milliporesigma.com.

Disclaimer

This product is regulated in France when intended for scientific purposes, including import, export, and conservation activities (Articles L.1211-1, paragraph 2, and L.1243-4 of the French Public Health Code). The purchaser (i.e. end user) is required to obtain an import authorization from the France Ministry responsible for Research (as referenced in Article L.1245-5-1 II of the French Public Health Code) or a conservation authorization from the same ministry (as referenced in Article L.1243-4 of the French Public Health Code). By placing an order for this product, you confirm that you have obtained the appropriate import or conservation authorization for the product. For more information regarding the use of human biological samples for research purposes in France, please contact the relevant French authorities.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable