SCC608

3dGRO^® Human Lung Organoids (PDXO.377)

Adenocarcinoma, Lung (Xenograph- Squamous), Age: 81, Female, Mutation: PIK3CA AMP

• Synonym(e): Lung PDO;Lung Tumor Organoid;Airway Organoid;Pulmonary Organoid, lung organoids
• UNSPSC Code: 41106509
• NACRES: NA.28

Eigenschaften

• Quality Segment: 100
• biological source: human lung (Xenograph- Squamous)
• packaging: vial of ≥ 1500 organoids/vial mg
• manufacturer/tradename: Millipore
• gender: female
• growth mode: N/A
• technique(s): cell culture: suitable
• application(s): 3D cell culture
• control: lung (Xenograph- Squamous)
• relevant disease(s): adenocardinoma
• shipped in: liquid nitrogen
• storage temp.: −196°C

Beschreibung

Application

• Each vial contains >1500 organoids.
• Mycoplasma: Negative
• Genotyped by STR analysis: Pass
• Human species verified
• Organoids are negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses by PCR.
• Cell viability test: Pass

Patient-derived lung organoids (lung PDOs) are adult tissue derived in vitro cultured “mini-lungs” that accurately replicate the histological and functional aspects of in vivo lung tissue. Lung organoids have been shown to contain all 6 major lung epithelial cell types including AEC2s, AEC1s, basal cells, club cells, goblet cells and ciliated cells. These 3D organoid models have become attractive alternatives to traditional PDX and animal lung models to study pulmonary diseases including COPD, cystic fibrosis, SARS-CoV-2, viral infections, asthma, and lung cancer. The 3dGRO^® Human Lung Organoids are high quality cryopreserved cell lines derived from patient-derived xenografts, primary tumors or metastatic patient tissues from various regions of the human lung (acinar, papillary, solid, squamous, mucinous). These lung organoids are highly characterized and express lung airway markers including EPCAM, cytokeratin (CK5, CK7), acetyl-α-tubulin, surfactant proteins (SFTPB/SFTPC), TTF1, P63 and Muc5AC.

Cell Line Characteristics

Sex: Female
Age: 81
Organ: Lung (PDX- Squamous)
Disease: Disease: Squamous Cell Carcinoma (Driver Mutations: PIK3CA AMP)

Features and Benefits

Cryopreserved Female Squamous Lung Organoids

Preparation Note

3dGRO^® human lung organoids should be stored in liquid nitrogen.

Legal Information

3dGRO^® is a trademark of Merck KGaA, Darmstadt, Germany.
3dGRO^® organoids were derived utilizing HUB Organoid Technology.

Subject to local law, this product is intended to be sold for internal in vitro research use only subject to terms and conditions found here: www.sigmaaldrich.com/pdouse. This product may not be re-engineered or copied; used to make derivatives or modifications; used to develop, test, or manufacture a commercial product; used as a component in a commercial product; resold or licensed; used in any clinical applications or trials; or used in humans. A license or limited commercial use agreement is required for use by any for-profit entity, use in services, and use in sponsored academic research. For information regarding any such use, please contact organoids@milliporesigma.com.

3dGRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

This product is regulated in France when intended for scientific purposes, including import, export, and conservation activities (Articles L.1211-1, paragraph 2, and L.1243-4 of the French Public Health Code). The purchaser (i.e. end user) is required to obtain an import authorization from the France Ministry responsible for Research (as referenced in Article L.1245-5-1 II of the French Public Health Code) or a conservation authorization from the same ministry (as referenced in Article L.1243-4 of the French Public Health Code). By placing an order for this product, you confirm that you have obtained the appropriate import or conservation authorization for the product. For more information regarding the use of human biological samples for research purposes in France, please contact the relevant French authorities.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable