This product is not tested for moisture content.
17850
Ciprofloxacin
≥98% (HPLC)
Ciprofloxacin
Synonym(e):
1-Cyclopropyl-6-fluor-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinolin-3-carboxylsäure, Ciprobay
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5 G
€ 33,10
25 G
€ 132,00
Über diesen Artikel
Empirische Formel (Hill-System):
C17H18FN3O3
CAS-Nummer:
Molekulargewicht:
331.34
Beilstein:
3568352
MDL-Nummer:
UNSPSC-Code:
41116105
PubChem Substanz-ID:
NACRES:
NA.21
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Unterstützung erhaltenAgentur
EPA 1694
Qualitätsniveau
Assay
≥98% (HPLC)
Form
powder or crystals
Wirkungsspektrum von Antibiotika
Gram-negative bacteria
Gram-positive bacteria
Anwendung(en)
environmental
Wirkungsweise
DNA synthesis | interferes
enzyme | inhibits
SMILES String
OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O
InChI
1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
InChIKey
MYSWGUAQZAJSOK-UHFFFAOYSA-N
Angaben zum Gen
human ... CYP1A2(1544), KCNH1(3756)
rat ... Gabra1(29705)
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Verwandte Kategorien
1 of 4
Dieser Artikel | 33434 | Y0000198 | 1134313 |
|---|---|---|---|
| mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level - |
| form powder or crystals | form - | form - | form - |
| application(s) environmental | application(s) agriculture | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
Allgemeine Beschreibung
Ciprofloxacin ist ein Breitspektrum-Fluorchinolon-Antibiotikum der zweiten Generation mit umfassenden antimikrobiellen und pharmakokinetischen Eigenschaften, das häufig zur Bekämpfung bakterieller Infektionen eingesetzt wird. Seine chemische Bezeichnung lautet 1-Cyclopropyl-6-fluor-4-oxo-7-(piperazin-1-yl)-1,4-dihydrochinolin-3-carbonsäure.[1][2]
Chemische Struktur: Fluorchinolon
Chemische Struktur: Fluorchinolon
Anwendung
Ciprofloxacin wird in der klinischen Praxis häufig gegen grampositive und gramnegative Bakterien und bei der Behandlung einer Vielzahl von Infektionen, einschließlich Infektionen der Haut, der Augen, der Harnwege, der unteren Atemwege, des Magen-Darm-Trakts usw. eingesetzt. Es kann auch mit verschiedenen antimikrobiellen Wirkstoffen zur Bekämpfung von bakteriellen Biofilmen sowie multiresistenten Mikroorganismen kombiniert werden.[1] Seine Derivate wurden entwickelt, um neuartige antibakterielle Wirkstoffe mit verbesserter Wirksamkeit und unterschiedlichen antimikrobiellen Wirkungen zu synthetisieren, darunter antibakterielle, antimykotische, anti-HIV-, anti-Tumor- und anti-TB-Eigenschaften.[2]
Biochem./physiol. Wirkung
Die Wirkmechanismen von Ciprofloxacin sind die Hemmung der bakteriellen DNA- Synthese durch Blockieren der Untereinheit A der DNA-Gyrase und die Beeinträchtigung der bakteriellen Zellwand.[1]
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 2
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic
Shariati et al.
Frontiers in public health, 10 (2022)
Gui-Fu Zhang et al.
European journal of medicinal chemistry, 146, 599-612 (2018-02-07)
Bacterial infections represent a significant health threat globally, and are responsible for the majority of hospital-acquired infections, leading to extensive mortality and burden on global healthcare systems. The second generation fluoroquinolone ciprofloxacin which exhibits excellent antimicrobial activity and pharmacokinetic properties
Athina Andrea et al.
Microorganisms, 7(3) (2019-03-22)
Among non-mammalian infection model organisms, the larvae of the greater wax moth Galleria mellonella have seen increasing popularity in recent years. Unlike other invertebrate models, these larvae can be incubated at 37 °C and can be dosed relatively precisely. Despite
Orjan Samuelsen et al.
Antimicrobial agents and chemotherapy, 54(1), 346-352 (2009-11-04)
Scandinavia is considered a region with a low prevalence of antimicrobial resistance. However, the number of multidrug-resistant (MDR) Gram-negative bacteria is increasing, including metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa. In this study MBL-producing P. aeruginosa isolates identified in Norway (n = 4)
Dongeun Yong et al.
Antimicrobial agents and chemotherapy, 53(12), 5046-5054 (2009-09-23)
A Swedish patient of Indian origin traveled to New Delhi, India, and acquired a urinary tract infection caused by a carbapenem-resistant Klebsiella pneumoniae strain that typed to the sequence type 14 complex. The isolate, Klebsiella pneumoniae 05-506, was shown to
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is this the anhydrous form of ciprofloxacin?
1 answer-
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Is Ciprofloxacin HCL available and is it USP grade?
1 answer-
Product 17850 has a molecular formula of C17H18FN3O3. The form of the chemical being searched for would have a molecular formula of C17H18FN3O3.HCL,H2O. There is Ciprofloxacin HCL.H2O but only in very small quantities as a secondary pharmaceutical standard, with the catalog number PHR1044. Regarding the question about whether the products are USP grade, the answer is no. Both products are labeled as strictly for Research Use Only and, as such, are not suitable for human use.
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Hi. Should I keep ciprofloxacin 17850-5g in refrigerator or -20? Thank you
1 answer-
In the powder form, this product is to be stored at tightly closed at room temperature. Solutions prepared in 1% HCl at 1 mg/ml may be stored in frozen aliquots at -20 °C for up to 12 months.
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What are the storage conditions of this product?
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This product is to be stored at room temperature.
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17850 Sigma-Aldrich Ciprofloxacin How much is the measured water content and active fraction of the above product?
1 answer-
This product is not tested for moisture content or potency/activity. The minimum purity of this product is 98% by HPLC. A similar product, PHR1167, is tested for loss on drying, but not potency/activity. This product typically demonstrates a >99% purity as compared to the USP and EP standards. See the link below to review this product option:
https://www.sigmaaldrich.com/US/en/product/sial/phr1167Helpful?
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If a stock solution of Cipro 17850 is solved in 0,1 HCl, at what temperature should it be stored and how long ist it stable?
1 answer-
Unfortunately, stability studies have not been performed on this product. However, several papers have information on the solution stability of ciprofloxacin.
(1) Stock solutions of ciprofloxacin in water at 200 mg/L, 100 mg/L, 40 mg/L, 20 mg/L and 4 mg/L can be stored at -20 °C for "at least 60 days.
http://www.clinchem.org/cgi/reprint/31/5/684.pdf
(2) Stock solutions of ciprofloxacin at 1 mg/mL in 1% HCl can be stored at -20 °C for at least 12 months.
http://onlinelibrary.wiley.com/doi/10.1002/bmc.1523/fullHelpful?
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Is ciprofloxacin 17850 soulable in water
1 answer-
This product is soluble in DMSO (<1 mg/ml at 25° C), methanol, 0.1N hydrochloric acid (25 mg/ml), and ethanol (<1 mg/ml at 25° C). It is insoluble in water.
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What is the solubility of Product 17850, Ciprofloxacin?
1 answer-
17850 is the free base of ciprofloxacin. It is soluble in 0.1N HCl at 25 mg/ml. Ciprofloxacin is poorly soluble in DMSO. For HPLC, dissolve the sample material in a mixture ofAcetonitril/Phosphoric acid pH 2.4 by ultrasonification (5 mg/10 ml solvent).
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Can Product 17850, Ciprofloxacin, be used in cell culture?
1 answer-
We have not done cell culture testing with this product.
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Can Product 17850, Ciprofloxacin, be used to remove Mycoplasma contaminations?
1 answer-
We have not tested the product for that application. However, there is a reference in Roche's Biochemica Newsletter Issue 1 from 1996 that describes using Ciprofloxacin in mycoplasma contamination.
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