The solubility of this product in NaOH has not been determined. However, other sources report that Ciprofloxacin is soluble at 3 mg/mL in 0.1 N NaOH. This information has not been validated. Note that this material is soluble in DMSO (<1 mg/ml at 25° C), methanol, 0.1N hydrochloric acid (25 mg/ml), and ethanol (<1 mg/ml at 25° C). It is insoluble in water.
Fortfahren mit
17850
Ciprofloxacin
≥98% (HPLC)
Synonym(e):
1-Cyclopropyl-6-fluor-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinolin-3-carboxylsäure, Ciprobay
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 g | Warenkorb auf Verfügbarkeit prüfen | € 34,20 |
25 g | Warenkorb auf Verfügbarkeit prüfen | € 136,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C17H18FN3O3
CAS-Nummer:
Molekulargewicht:
331.34
UNSPSC Code:
41116105
NACRES:
NA.21
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3568352
eCl@ss:
32120505
Technischer Dienst
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Unterstützung erhaltenagency
EPA 1694
Quality Segment
assay
≥98% (HPLC)
form
powder or crystals
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
application(s)
environmental
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O
InChI
1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
InChI key
MYSWGUAQZAJSOK-UHFFFAOYSA-N
Gene Information
human ... CYP1A2(1544), KCNH1(3756)
rat ... Gabra1(29705)
General description
Ciprofloxacin ist ein Breitspektrum-Fluorchinolon-Antibiotikum der zweiten Generation mit umfassenden antimikrobiellen und pharmakokinetischen Eigenschaften, das häufig zur Bekämpfung bakterieller Infektionen eingesetzt wird. Seine chemische Bezeichnung lautet 1-Cyclopropyl-6-fluor-4-oxo-7-(piperazin-1-yl)-1,4-dihydrochinolin-3-carbonsäure.
Chemische Struktur: Fluorchinolon
Chemische Struktur: Fluorchinolon
Application
Ciprofloxacin wird in der klinischen Praxis häufig gegen grampositive und gramnegative Bakterien und bei der Behandlung einer Vielzahl von Infektionen, einschließlich Infektionen der Haut, der Augen, der Harnwege, der unteren Atemwege, des Magen-Darm-Trakts usw. eingesetzt. Es kann auch mit verschiedenen antimikrobiellen Wirkstoffen zur Bekämpfung von bakteriellen Biofilmen sowie multiresistenten Mikroorganismen kombiniert werden. Seine Derivate wurden entwickelt, um neuartige antibakterielle Wirkstoffe mit verbesserter Wirksamkeit und unterschiedlichen antimikrobiellen Wirkungen zu synthetisieren, darunter antibakterielle, antimykotische, anti-HIV-, anti-Tumor- und anti-TB-Eigenschaften.
Biochem/physiol Actions
Die Wirkmechanismen von Ciprofloxacin sind die Hemmung der bakteriellen DNA- Synthese durch Blockieren der Untereinheit A der DNA-Gyrase und die Beeinträchtigung der bakteriellen Zellwand.
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Dieser Artikel | |||
|---|---|---|---|
| description ≥98% (HPLC) | description VETRANAL®, analytical standard | description Pharmaceutical Secondary Standard; Certified Reference Material | description United States Pharmacopeia (USP) Reference Standard |
| mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - | mode of action - |
| antibiotic activity spectrum Gram-positive bacteria, Gram-negative bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 100 | Quality Level 300 | Quality Level - |
| application(s) environmental | application(s) agriculture | application(s) pharmaceutical | application(s) pharmaceutical (small molecule) |
| form powder or crystals | form - | form - | form - |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
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I am using ciprofloxacin (Product No. 17850) for research and would like to know if it can be dissolved directly in 0.1 M NaOH to prepare a stock solution. Is 0.1 M NaOH a recommended solvent, or could it affect the stability of the compound?
1 answer-
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What is the ratio used to dilute ciprofloxacin in saline solution? 0.05 g in 10 ml?
1 answer-
This product has very limited solubility in water, rates of approximately 80 ug/mL are reported in the literature. This material is soluble in 0.1 N HCl at 25 mg/mL. Stock solutions are typically diluted in aqueous buffers or medium. External sources indicate that stock solutions may be diluted with 5% dextrose or normal saline to a concentration of 1 – 2 mg/mL. This information has not been validated.
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can we use analytical grade ciprofloxacin in patients
1 answer-
This product is intended for research use only. Unfortunately, there is not a pharmaceutical grade Ciprofloxacin product currently offered. Unless otherwise stated this product is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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is this the anhydrous form of ciprofloxacin?
1 answer-
This product is not tested for moisture content.
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Is Ciprofloxacin HCL available and is it USP grade?
1 answer-
Product 17850 has a molecular formula of C17H18FN3O3. The form of the chemical being searched for would have a molecular formula of C17H18FN3O3.HCL,H2O. There is Ciprofloxacin HCL.H2O but only in very small quantities as a secondary pharmaceutical standard, with the catalog number PHR1044. Regarding the question about whether the products are USP grade, the answer is no. Both products are labeled as strictly for Research Use Only and, as such, are not suitable for human use.
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Hi. Should I keep ciprofloxacin 17850-5g in refrigerator or -20? Thank you
1 answer-
In the powder form, this product is to be stored at tightly closed at room temperature. Solutions prepared in 1% HCl at 1 mg/ml may be stored in frozen aliquots at -20 °C for up to 12 months.
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What are the storage conditions of this product?
1 answer-
This product is to be stored at room temperature.
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17850 Sigma-Aldrich Ciprofloxacin How much is the measured water content and active fraction of the above product?
1 answer-
This product is not tested for moisture content or potency/activity. The minimum purity of this product is 98% by HPLC. A similar product, PHR1167, is tested for loss on drying, but not potency/activity. This product typically demonstrates a >99% purity as compared to the USP and EP standards. See the link below to review this product option:
https://www.sigmaaldrich.com/US/en/product/sial/phr1167Helpful?
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If a stock solution of Cipro 17850 is solved in 0,1 HCl, at what temperature should it be stored and how long ist it stable?
1 answer-
Unfortunately, stability studies have not been performed on this product. However, several papers have information on the solution stability of ciprofloxacin.
(1) Stock solutions of ciprofloxacin in water at 200 mg/L, 100 mg/L, 40 mg/L, 20 mg/L and 4 mg/L can be stored at -20 °C for "at least 60 days.
http://www.clinchem.org/cgi/reprint/31/5/684.pdf
(2) Stock solutions of ciprofloxacin at 1 mg/mL in 1% HCl can be stored at -20 °C for at least 12 months.
http://onlinelibrary.wiley.com/doi/10.1002/bmc.1523/fullHelpful?
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Is ciprofloxacin 17850 soulable in water
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This product is soluble in DMSO (<1 mg/ml at 25° C), methanol, 0.1N hydrochloric acid (25 mg/ml), and ethanol (<1 mg/ml at 25° C). It is insoluble in water.
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