33899

Norfloxacin

VETRANAL^®, analytical standard

• Synonym(e): 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsäure, 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-3-chinolincarbonsäure
• Empirische Formel (Hill-System): C₁₆H₁₈FN₃O₃
• CAS-Nummer: 70458-96-7
• Molekulargewicht: 319.33
• NACRES: NA.24
• PubChem Substance ID: 329754535
• UNSPSC Code: 41116107
• EC Number: 274-614-4
• MDL number: MFCD00079532

Eigenschaften

• Produktname: Norfloxacin, VETRANAL^®, analytical standard
• InChI: 1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
• InChI key: OGJPXUAPXNRGGI-UHFFFAOYSA-N
• SMILES string: CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCNCC3
• grade: analytical standard
• agency: EPA 1694
• product line: VETRANAL^®
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): clinical testing
• format: neat
• storage temp.: 2-8°C
• Quality Level: 100

Beschreibung

Biochem/physiol Actions

Norfloxacin blockiert die DNA-Replikation durch Wechselwirkung mit einer ATP-induzierten strukturellen Transition der mit DNS-Gyrase (Topoisomerase) komplexierten DNA.
Wirkungsweise: hemmt die bakterielle DNA-Replikation
Antimikrobielles Spektrum: Gram-negative Bakterien, weniger effektiv bei Gram-positiven Bakterien

Application

Norfloxacin may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations,[1] biological fluids[1] and sewage[2] using various chromatography techniques.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Norfloxacin is an antimicrobial drug, belonging to the class of fluoroquinolones (FQs), which shows broad-spectrum activity against a wide range of Gram-negative and Gram-positive organisms.[1]

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)