94646

Poly(ethylenglykol)

BioUltra, 35,000

• Synonym(e): PEG
• Lineare Formel: H(OCH₂CH₂)_nOH
• CAS-Nummer: 25322-68-3
• NACRES: NA.26
• PubChem Substance ID: 24890034
• UNSPSC Code: 12352104
• MDL number: MFCD00081839

Eigenschaften

• Quality Segment: 200
• product line: BioUltra
• form: powder or crystals (or flakes)
• mol wt: M_r ~35000
• greener alternative product characteristics: Safer Solvents and Auxiliaries; Learn more about the Principles of Green Chemistry.
• sustainability: Sustainability features
• impurities: insoluble matter:, passes filter test, ≤0.005% peroxides (as H₂O₂):
• pH: 5.5-7.0 (25 °C, 50 mg/mL in H₂O)
• mp: 64-66 °C
• solubility: H₂O: 50 mg/mL at 25 °C, clear, colorless
• anion traces: chloride (Cl^-): ≤50 mg/kg, sulfate (SO₄^2-): ≤50 mg/kg
• cation traces: Al: ≤5 mg/kg, As: ≤0.1 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤200 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤200 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg
• λ: 50 mg/mL in H₂O
• UV absorption: λ: 260 nm A_max: 0.12, λ: 280 nm A_max: 0.12
• SMILES string: C(CO)O
• InChI: 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
• InChI key: LYCAIKOWRPUZTN-UHFFFAOYSA-N

Beschreibung

General description

Polyethylene glycol (PEG) is a polyether compound that is used as an additive in cosmetics, pharmaceuticals, and food. It consists of repeated ethylene glycol units[-(CH₂CH₂O)_n].

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. Polyethylene glycol (PEG) is an eco-friendly, biodegradable polymer widely used in pharmaceuticals and cosmetics. Its non-toxic nature and versatility make it a sustainable choice, derived from renewable resources, contributing to greener product formulations. Click here for more information.

Application

Poly(ethylene glycol) has been used:

• as a component of University of Wisconsin (UW) cold preservation solutions to stabilize the cell membrane of hepatocytes during temperature changes
• as a component of the supercooling solution to study supercooling preservation technique of the rat liver for transplantation and to protect against hypothermic injury
• to prepare aqueous phase for the fabrication of multicellular spheroid (MCS) cultures

Biochem/physiol Actions

Polyethylene glycol (PEG) is a synthetic polymer that is used as a gold standard in bioconjugation and nanomedicine to extend blood circulation time and enhance drug efficacy. It acts as an ice-modulator by preventing ice crystallization, which is beneficial for cellular membranes. PEG provides protection against hypothermic injury, like lipid peroxidation and cell membrane injury. PEG-conjugated drugs are considered safe for use in humans and are approved by the U.S. Food and Drug Administration (FDA). PEG has several biomedical applications, including biosensing, imaging, and tissue engineering. It also repels protein adsorption and lowers the liver uptake, which helps in coating nanoparticles.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)