A9611

Atipamezole

≥98% (HPLC), α2-adrenoceptor antagonist, powder

• Synonym(e): 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-Imidazole, Antisedan, MPV 1248
• Empirische Formel (Hill-System): C₁₄H₁₆N₂
• CAS-Nummer: 104054-27-5
• Molekulargewicht: 212.29
• UNSPSC Code: 12352200
• PubChem Substance ID: 329771055
• NACRES: NA.77
• MDL number: MFCD00864502
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Atipamezole, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to brown
• solubility: DMSO: ≥30 mg/mL
• storage temp.: room temp
• SMILES string: CCC1(Cc2ccccc2C1)c3c[nH]cn3
• InChI: 1S/C14H16N2/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14/h3-6,9-10H,2,7-8H2,1H3,(H,15,16)
• InChI key: HSWPZIDYAHLZDD-UHFFFAOYSA-N

Beschreibung

General description

Atipamezole has an imidazole structure and gets localized in the central nervous system on administration.

Application

Atipamezole has been used as a α2-adrenoceptor antagonist in mesencephalic trigeminal nucleus (MTN) neurons, CD4+ T-lymphocyte and human embryonic kidney (HEK293) membrane preparation.

Biochem/physiol Actions

Atipamezole elicits affinity towards adrenoreceptor subtypes namely α2A, α2B and α2C. High levels of atipamezole impairs cognitive functions. It also reverses the adrenoreceptor agonist functionalities. Atipamezole shows no affinity towards muscarinic and dopamine or neurotransmitter receptors. Atipamezole when used along with morphine elicits antinociceptive effects.

Atipamezole is a selective α₂ adrenergic blocker. Atipamezole is more potent than yohimbine; it is very selective for α₂ adrenergic vs α₁ sites, but not selelctive for α₂ subtypes.

Atipamezole is a selective α₂ adrenergic blocker; neutral antagonist

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable