Solubility is tested up to 10mg/mL in anhydrous DMSO. Capsazepine should not be reconstituted in aqueous solutions such as water.
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C191
Capsazepine
≥98% (HPLC), solid, TRPV1 antagonist
Synonym(e):
N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Warenkorb auf Verfügbarkeit prüfen | € 176,00 |
25 mg | Warenkorb auf Verfügbarkeit prüfen | € 596,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C19H21ClN2O2S
CAS-Nummer:
Molekulargewicht:
376.90
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Technischer Dienst
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Unterstützung erhaltenProduktname
Capsazepine, ≥98% (HPLC), solid
Quality Segment
assay
≥98% (HPLC)
form
solid
color
off-white
solubility
DMSO: >10 mg/mL, clear
storage temp.
2-8°C
SMILES string
Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc3ccc(Cl)cc3
InChI
1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
InChI key
DRCMAZOSEIMCHM-UHFFFAOYSA-N
Gene Information
human ... TRPV1(7442), TRPV4(59341)
rat ... Trpv1(83810)
Application
Capsazepine has been used as a transient receptor potential vanilloid-1 (TRPV1) antagonist:
- to study its effect on capsaicin induced extracellular signal-regulated kinase (ERK) phosphorylation
- to study the role of TRPV1 in central terminals on nociception in rats
- for functional characterization of the TRPV1 in bull spermatozoa
Biochem/physiol Actions
Capsazepine is a synthetic analog of capsaicin and a transient receptor potential vanilloid-1 (TRPV1) antagonist. It exhibits anti-proliferative and anti-cancer effects in various cancer types including oral squamous cell carcinoma, non-small cell lung cancer (NSCLC), breast cancer, and prostate cancer cell lines (HSC-3, H460, MDA-231, and PC-3 respectively). Capsazepine recovers impaired lung mechanics during endotoxemia and it may be a potential therapeutic target for acute lung injury (ALI).
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Dieser Artikel | |||
|---|---|---|---|
| description ≥98% (HPLC), solid | description A competitive antagonist of Capsaicin and resiniferatoxin. Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers. | description natural | description ≥90.0% (HPLC) |
| form solid | form solid | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥97% (HPLC) | assay 63.7% (HPLC) | assay ≥90.0% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 10-30°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: >10 mg/mL, clear | solubility methanol: soluble, DMSO: soluble | solubility chloroform: 5% | solubility - |
| color off-white | color off-white | color - | color - |
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Lagerklasse
11 - Combustible Solids
Was ist los?
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
PSA (Persönliche Schutzausrüstung)
Eyeshields, Gloves, type N95 (US)
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With respect to product number catalog C191, concentrations below 10 mg/ml can be diluted with water?
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