C2648

Cholesterol 5β,6β-epoxide

≥98%

• Synonym(e): 5β,6β-Epoxycholestan-3β-ol
• Empirische Formel (Hill-System): C₂₇H₄₆O₂
• CAS-Nummer: 4025-59-6
• Molekulargewicht: 402.65
• NACRES: NA.28
• PubChem Substance ID: 24892511
• UNSPSC Code: 12352211
• MDL number: MFCD00201258

Eigenschaften

• Quality Segment: 100
• assay: ≥98%
• form: powder
• functional group: epoxy
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)[C@]3(O4)[C@H]4C2)([H])CC[C@@]5(C)[C@@]1([H])CC[C@]5([H])[C@]([H])(C)CCCC(C)C
• InChI: 1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24-27(29-24)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-24,28H,6-16H2,1-5H3
• InChI key: PRYIJAGAEJZDBO-UHFFFAOYSA-N

Beschreibung

Application

Cholesterol 5β,6β-epoxide was used to treat PC12 cells or HepG2 and Caco-2 cells to study the effects of cholesterol oxidation.

Biochem/physiol Actions

Cholesterol 5β,6β-epoxide is an oxysterol produced as an oxidation product of cholesterol. Oxysterols are cytotoxic and induce death in monocytes, smooth muscle cells and endothelial cells. The mechanism of apoptosis induced by oxysterols may involve caspases or DNA fragmentation.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves