C5988

Anti-Calcium Channel (β₁ subunit) antibody produced in rabbit

~1 mg/mL, fractionated antiserum, buffered aqueous solution

• Synonym(e): Anti-Voltage-dependent L-type calcium channel, β₁ subunit
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD01633054
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 5

Eigenschaften

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: fractionated antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: rat, mouse, human
• concentration: ~1 mg/mL
• technique(s): western blot: 5-10 μg/mL using rat brain tissue lysate
• UniProt accession no.: Q02641
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CACNB1(782) ; mouse ... Cacnb1(12295) ; rat ... Cacnb1(50688)

Beschreibung

General description

The gene CACNB1 (Calcium channel voltage-dependent subunit β 1) is mapped to human chromosome 17q11.2-q22.

Immunogen

synthetic peptide derived from the rat β1 calcium channel conjugated to KLH.

Application

Anti-Calcium Channel (β1 subunit) antibody produced in rabbit is suitable for western blot at a concentration of 5-10 μg/mL using rat brain tissue lysate

Biochem/physiol Actions

The CACNB1 (Calcium channel voltage-dependent subunit β 1) is an intracellular regulatory subunit of voltage-activated calcium channels that has significant impact on membrane expression and electrophysical characteristics of the channel. Calcium channel β subunits regulate voltage-dependent calcium currents through direct interaction with α1 subunits. CACNB1 is a target of miRNA-328. In mouse model, CACNB1 is involved in gene expression in muscle progenitor cells and regulates skeletal muscle mass during embryonic development by suppressing myogenin.

Physical form

Solution in phosphate buffered saline containing 0.08% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids