C9915

ω-Conotoxin GVIA

≥97% (HPLC)

• Empirische Formel (Hill-System): C₁₂₀H₁₈₂N₃₈O₄₃S₆
• CAS-Nummer: 106375-28-4
• Molekulargewicht: 3037.35
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD00076620

Eigenschaften

• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: powder
• composition: Peptide content, ~70%
• storage temp.: −20°C
• Gene Information: human ... CACNA1B(774) ; mouse ... CACNA1B(12287) ; rat ... CACNA1B(257648)

Beschreibung

Application

Powerful probe for exploring the vertebrate pre-synaptic terminal.

ω-Conotoxin GVIA has been used as an antagonist for N-type calcium channel (CaV2.2) in various studies.

Biochem/physiol Actions

Blocks specific voltage-dependent N-type Ca²⁺ channels in neurons, but not in muscle; does not bind to either the dihydropyridine or verapamil binding sites; peptide first isolated from the marine snail Conus geographus L.

ω-Conotoxin GVIA is a 27 amino acid neurotoxin containing three disulfide bonds. It inhibits central neurotransmitter release and also exhibits antihypertensive, analgesic and neuroprotective activities.

Other Notes

Lyophilized from 0.1% TFA in H2O

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)