D5314

DPQ

≥98% (HPLC), solid

• Synonym(e): 3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone
• Empirische Formel (Hill-System): C₁₈H₂₆N₂O₂
• CAS-Nummer: 129075-73-6
• Molekulargewicht: 302.41
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD01866274
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: solid
• mp: 107-109 °C
• solubility: DMSO: 1 mg/mL, clear, colorless to faintly yellow
• storage temp.: 2-8°C
• SMILES string: N3(CCCCC3)CCCCOc1c2c(ccc1)C(=O)NCC2
• InChI: 1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
• InChI key: RVOUDNBEIXGHJY-UHFFFAOYSA-N

Beschreibung

Application

DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.

Biochem/physiol Actions

DPQ is a very potent poly(ADP-ribose) polymerase (PARP) inhibitor.

3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves