D7321

Diosmetin

• Synonym(e): 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-chromen-4-on, 3′,5,7-Trihydroxy-4′-methoxy-flavon, 4′-Methyl-luteolin, Luteolin-4′-methylether
• Empirische Formel (Hill-System): C₁₆H₁₂O₆
• CAS-Nummer: 520-34-3
• Molekulargewicht: 300.26
• UNSPSC Code: 12352205
• NACRES: NA.25
• PubChem Substance ID: 329798848
• EC Number: 208-291-8
• Beilstein/REAXYS Number: 294492
• MDL number: MFCD00017425

Eigenschaften

• assay: ≥98% (HPLC)
• Quality Segment: 200
• form: powder
• color: light yellow to yellow
• solubility: DMSO: 1 mg/mL, clear, faintly yellow to greenish-yellow
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3
• InChI key: MBNGWHIJMBWFHU-UHFFFAOYSA-N

Beschreibung

General description

Diosmetin is a methylated aglycone flavone of diosmin. It is present abundantly in citrus fruits, Olea europaea L. (olive tree) leaves, and in the legume of Acacia farnesiana tree.

Application

Diosmetin has been used to test its protective effects on chronic stress memory and cognitive impairment in mice model.

Biochem/physiol Actions

Diosmetin exhibits anti-inflammatory, anti-cancer, antimicrobial, phytoestrogenic, and neuroprotective properties. It displays cytoprotective effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) by inhibiting nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and activating nuclear factor erythroid 2–related factor 2 (Nrf2).

Flavonoid aus Citrus limon. Antioxidans. Hemmt Aktivierung von Karzinogenen durch die Hemmung des CYP1A1-Enzyms.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable