D7692

Diethylumbelliferyl phosphate

≥98% (HPLC), cholesterol esterase inhibitor, oil

• Synonym(e): DEUP, UBP
• Empirische Formel (Hill-System): C₁₄H₁₇O₆P
• CAS-Nummer: 897-83-6
• Molekulargewicht: 312.25
• UNSPSC Code: 12352200
• PubChem Substance ID: 24894155
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: oil

Eigenschaften

• Produktname: Diethylumbelliferyl phosphate, ≥98% (HPLC), oil
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: oil
• color: colorless to yellow
• solubility: DMSO: >5 mg/mL
• storage temp.: −20°C
• SMILES string: CCOP(=O)(OCC)Oc1ccc2C(C)=CC(=O)Oc2c1
• InChI: 1S/C14H17O6P/c1-4-17-21(16,18-5-2)20-11-6-7-12-10(3)8-14(15)19-13(12)9-11/h6-9H,4-5H2,1-3H3
• InChI key: GHGRYKAFUNNHBG-UHFFFAOYSA-N

Beschreibung

Application

Diethylumbelliferyl phosphate has been used as a lipase inhibitor to treat wild-type myeloblasts for in vitro neutrophil differentiation assays.

Biochem/physiol Actions

Diethylumbelliferyl phosphate (DEUP), an organophosphate does not block protein kinase activity A in vitro.

Diethylumbelliferyl phosphate is a selective, potent cholesterol esterase inhibitor. It blocks steroidogenesis primarily by preventing cholesterol transport into the mitochondria of steroidogenic cells. Inhibitors of cholesterol esterase are anticipated to limit the absorption of dietary cholesterol. IC₅₀ = 11.6 μM.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H300
• Sicherheitshinweise: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges