E7275

Anti-Ephrin-A4 antibody produced in goat

affinity isolated antibody, lyophilized powder

• UNSPSC Code: 51111800
• NACRES: NA.41
• MDL number: MFCD02096316
• Conjugate: unconjugated
• Clone: polyclonal
• Application: ELISA (i), WB
• Citations: 3

Eigenschaften

• biological source: goat
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: human
• technique(s): indirect ELISA: 0.5-1.0 μg/mL, western blot: 0.1-0.2 μg/mL
• UniProt accession no.: P52798
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... EFNA4(1945)

Beschreibung

General description

By ELISA, the antibody shows approximately 50% cross-reactivity with recombinant human ephrin-A5 and no cross-reactivity with recombinant mouse ephrin-A1, mouse ephrin-A2, human ephrin-A3, mouse ephrin-B1, mouse ephrin-B2, and mouse ephrin B3.

Immunogen

recombinant human ephrin-A4, extracellular domain, expressed in NSO cells.

Biochem/physiol Actions

Ephrin A4 binds to EPH receptor A4, a protein-tyrosine kinase family that belongs to the ephrin receptor subfamily. The ephrin-A and ephrin-B ligands and regulate developmental events, particularly those of the nervous system. EphrinA4 regulates the axonal growth, astrocyte reactivity and neuroinflammation in experimental autoimmune encephalomyelitis. High expression of EphA4 receptor correlates with tumor progression, invasion and metastasis of gastric cancer and is a suitable prognostic marker.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids