F5130

5-Fluoruridin

≥99% (HPLC), synthetic (organic), powder

• Synonym(e): 5-Fluor-uracil-1β-D-ribofuranosid, FUrd
• Empirische Formel (Hill-System): C₉H₁₁FN₂O₆
• CAS-Nummer: 316-46-1
• Molekulargewicht: 262.19
• NACRES: NA.51
• PubChem Substance ID: 24894883
• UNSPSC Code: 41106305
• EC Number: 206-260-3
• MDL number: MFCD00036832
• Beilstein/REAXYS Number: 33662
• eCl@ss: 32119108
• Assay: ≥99% (HPLC)
• Biological source: synthetic (organic)
• Form: powder
• Solubility: water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

Eigenschaften

• Produktname: 5-Fluoruridin, proapoptotic anitproliferative plant growth regulator
• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥99% (HPLC)
• form: powder
• solubility: water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• SMILES string: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=C(F)C(=O)NC2=O
• InChI: 1S/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1
• InChI key: FHIDNBAQOFJWCA-UAKXSSHOSA-N

Beschreibung

General description

5-Fluorouridine (FUrd) is a fluoropyrimidine nucleoside analog and a cell-permeable modified RNA precursor.

Application

5-Fluorouridine has been used for labeling active transcription sites in the porcine fetal fibroblasts and human cell lines for immunocytochemistry analysis. It has also been used to monitor apoptosis during drug sensitivity assay in esophageal squamous cell carcinoma (ESCC) cells.

Biochem/physiol Actions

5-Fluorouridine (FUrd) is cytotoxic towards cancer cells. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves