F8307

FR-900098 monosodium salt

≥97% (NMR)

• Synonym(e): (3-(Acetylhydroxyamino)propyl)-phosphonic acid, BRN 2096083, P-[3-(Acetylhydroxyamino)propyl]-phosphonic acid
• Empirische Formel (Hill-System): C₅H₁₁NNaO₅P
• CAS-Nummer: 73226-73-0
• Molekulargewicht: 219.11
• NACRES: NA.77
• PubChem Substance ID: 329799770
• UNSPSC Code: 51111800
• MDL number: MFCD17215926
• Assay: ≥97% (NMR)
• Form: powder
• Storage condition: desiccated, protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥97% (NMR)
• form: powder
• storage condition: desiccated, protect from light
• color: white to light brown
• solubility: H₂O: ≥20 mg/mL
• storage temp.: −20°C
• SMILES string: [Na+].CC(=O)N(O)CCCP(O)([O-])=O
• InChI: 1S/C5H12NO5P.Na/c1-5(7)6(8)3-2-4-12(9,10)11;/h8H,2-4H2,1H3,(H2,9,10,11);/q;+1/p-1
• InChI key: LCFXFDGYDKNWMD-UHFFFAOYSA-M

Beschreibung

Biochem/physiol Actions

1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway). Inhibiton of the enzyme provides alternative to traditional antimalaria therapy. FR-900098 is twice more effective than fosmidomycin against various strains of P. falciparum in vitro and the closely related P. vinckei in mice.

1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable