GS71

GST K1-1, Recombinant Human

• Synonym(e): GST, GST 13-13, GST13, GST13-13, GSTK1-1, glutathione S-transferase kappa, hGSTK1
• NACRES: NA.26
• UNSPSC Code: 12352200
• Form: frozen liquid
• Assay: >95% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in E. coli
• Mol wt: 26 kDa

Eigenschaften

• biological source: human
• recombinant: expressed in E. coli
• assay: >95% (SDS-PAGE)
• form: frozen liquid
• specific activity: 12.22 units/mg protein
• mol wt: 26 kDa
• concentration: 3.17 mg/mL
• storage temp.: −70°C
• Gene Information: human ... GSTK1(373156)

Beschreibung

General description

using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.

Biochem/physiol Actions

Glutathione S-transferase kappa 1 (GSTK1) is an enzyme that in humans is encoded by the GSTK1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.

Preparation Note

The enzyme should be used by the end-user customer within 1 year of receipt.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• Was ist los?: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable