GW20008F

Anti-α-2-Macroglobulin antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-A2MG
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD00162122
• Conjugate: unconjugated
• Clone: polyclonal
• Application: ELISA (i), WB
• Citations: 6

Eigenschaften

• biological source: chicken
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human, mouse, rat
• manufacturer/tradename: Genway 15-288-20008F
• technique(s): indirect ELISA: suitable, western blot: suitable
• NCBI accession no.: MAHU
• UniProt accession no.: P01023
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... A2M(2)

Beschreibung

Immunogen

α-2-Macroglobulin (validated) native human protein.

Immunogen Sequence: GI # 68765, sequence 1-1474

Application

Anti-α-2-Macroglobulin antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200. It is also used for indirect ELISA.

Biochem/physiol Actions

A2M (α-2-macroglobulin) inhibits all four classes of proteinases by a unique ′trapping′ mechanism. This protein undergoes a conformational change when a proteinase binds and cleaves a specific peptide stretch called the "bait region" in the protein. This modified protein traps the bound proteinase It is involved in the clearance and degradation of Aβ, which is a major component of beta-amyloid deposits. Therefore, it is associated with Alzheimer′s disease (AD).

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• Was ist los?: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)