J4137

JS-K

≥97%, Nitric oxide donor

• Synonym(e): O2-(2,4-Dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate
• Empirische Formel (Hill-System): C₁₃H₁₆N₆O₈
• CAS-Nummer: 205432-12-8
• Molekulargewicht: 384.30
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724519
• NACRES: NA.77
• MDL number: MFCD06407868
• Assay: ≥97%
• Storage condition: desiccated

Eigenschaften

• Produktname: JS-K, ≥97%
• Quality Segment: 100
• assay: ≥97%
• storage condition: desiccated
• solubility: DMSO: soluble 9.3 mg/mL, H₂O: insoluble
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CCOC(=O)N1CCN(CC1)\[N+]([O-])=N\Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O
• InChI: 1S/C13H16N6O8/c1-2-26-13(20)15-5-7-16(8-6-15)19(25)14-27-12-4-3-10(17(21)22)9-11(12)18(23)24/h3-4,9H,2,5-8H2,1H3/b19-14-
• InChI key: DNJRNBYZLPKSHV-RGEXLXHISA-N

Beschreibung

Biochem/physiol Actions

JS-K belongs to the class of diazeniumdiolate prodrug. It generates nitric oxide when metabolized by glutathione S-transferases (GST), which ensures optimal activity of JS-K. It has tumor growth inhibition action in human prostate cancer and leukemia.

Nitric oxide donor; antiproliferative.

Legal Information

Covered by US Patent No 6,610,660

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)