L135

L-741,626

≥98% (HPLC)

• Synonym(e): (±)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole
• Empirische Formel (Hill-System): C₂₀H₂₁ClN₂O
• CAS-Nummer: 81226-60-0
• Molekulargewicht: 340.85
• NACRES: NA.77
• PubChem Substance ID: 24278529
• UNSPSC Code: 12352200
• MDL number: MFCD00953632
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥20 mg/mL, ethanol: 24 mg/mL, H₂O: insoluble
• storage temp.: room temp
• SMILES string: OC1(CCN(CC1)Cc2c[nH]c3ccccc23)c4ccc(Cl)cc4
• InChI: 1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2
• InChI key: LLBLNMUONVVVPG-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813), DRD3(1814), DRD4(1815)

Beschreibung

Application

L-741,626 has been used as selective dopamine (D₂) receptor antagonist to study its effects on the uptake of dopamine in human embryonic kidney 293 (HEK293) cells. It has also been used as a D₂ receptor antagonist to study its effects on thyrotropin-releasing hormone (TRH) induced prolactin release.

Biochem/physiol Actions

L-741,626 is a selective dopamine (D₂) receptor antagonist.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)