M2672

(±)-α-Methyl-(4-tetrazolylphenyl)glycine

• Empirische Formel (Hill-System): C₁₀H₁₁N₅O₂
• CAS-Nummer: 169209-66-9
• Molekulargewicht: 233.23
• UNSPSC Code: 12352202
• PubChem Substance ID: 329817948
• MDL number: MFCD00672653

Eigenschaften

• form: solid
• storage temp.: 2-8°C
• SMILES string: CC(N)(C(O)=O)c1ccc(cc1)-n2cnnn2
• InChI: 1S/C10H11N5O2/c1-10(11,9(16)17)7-2-4-8(5-3-7)15-6-12-13-14-15/h2-6H,11H2,1H3,(H,16,17)
• InChI key: PUQSGMIEFYCTSW-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

(±)-α-Methyl-(4-tetrazolylphenyl)glycine (MTPG) was used in rat models of cerebral ischemia to explore the role of group II metabotropic glutamate receptors mGluR2/3 in brain ischemia tolerance. MTPG inhibited the induction of ischemia tolerance indicating the involvement of mGluR2/3 in the induction of the protective mechanism.

Potent antagonist for (1S,3S)-ACPD-sensitive receptors; preference for GluR₂ and GluR₃ subtypes

Sicherheitshinweise

• Lagerklasse: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)