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Fortfahren mit
M5525
4-(N-Maleimidomethyl)cyclohexan-Carboxylsäure N-hydroxysuccinimid-Ester
≥98%, powder
Synonym(e):
N-Succinimidyl-4-(maleinimidomethyl)-cyclohexancarboxylat, SMCC
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Warenkorb auf Verfügbarkeit prüfen | € 39,70 |
25 mg | Warenkorb auf Verfügbarkeit prüfen | € 119,00 |
100 mg | Warenkorb auf Verfügbarkeit prüfen | € 359,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C16H18N2O6
CAS-Nummer:
Molekulargewicht:
334.32
UNSPSC Code:
12352103
NACRES:
NC.07
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1555271
Assay:
≥98%
Form:
powder
Technischer Dienst
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Unterstützung erhaltenQuality Segment
assay
≥98%
form
powder
reaction suitability
reagent type: linker
technique(s)
targeted protein degradation: suitable
mp
180-182 °C (lit.)
solubility
chloroform: 50 mg/mL, DMF: soluble
functional group
NHS ester
shipped in
wet ice
storage temp.
−20°C
SMILES string
O=C(ON1C(CCC1=O)=O)C2CCC(CN3C(C=CC3=O)=O)CC2
InChI
1S/C16H18N2O6/c19-12-5-6-13(20)17(12)9-10-1-3-11(4-2-10)16(23)24-18-14(21)7-8-15(18)22/h5-6,10-11H,1-4,7-9H2
InChI key
JJAHTWIKCUJRDK-UHFFFAOYSA-N
General description
4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.
Application
4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. It has been used for the coupling of a peptide sequence to an amino group.
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Dieser Artikel | |||
|---|---|---|---|
| description ≥98%, powder | description - | description powder | description ≥98%, powder |
| assay ≥98% | assay ≥97% (HPLC) | assay - | assay ≥98% |
| solubility DMF: soluble, chloroform: 50 mg/mL | solubility acetonitrile: soluble, DMF: 10 mg/mL | solubility H2O: 2.5 mg/mL, DMF: soluble | solubility DMF: soluble (lit.)(lit.), chloroform: 100 mg/mL |
| reaction suitability reagent type: linker | reaction suitability - | reaction suitability reagent type: linker | reaction suitability reagent type: linker |
| Quality Level 200 | Quality Level 100 | Quality Level 300 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| form powder | form solid | form powder | form powder |
Lagerklasse
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
PSA (Persönliche Schutzausrüstung)
dust mask type N95 (US), Eyeshields, Gloves
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¿Qué caducidad se puede dar al producto M5525 almacenado a -20ºC?
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