M7945

Mephetyl tetrazole

≥98% (HPLC), oil

• Synonym(e): 1-[2-(4-Methoxyphenyl)ethyl]-5-(1-p-tolylcyclopropyl)-1H-tetrazole
• Empirische Formel (Hill-System): C₂₀H₂₂N₄O
• CAS-Nummer: 916923-10-9
• Molekulargewicht: 334.41
• NACRES: NA.77
• PubChem Substance ID: 329818044
• UNSPSC Code: 12352200
• MDL number: MFCD11045297
• Assay: ≥98% (HPLC)
• Form: oil

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: oil
• color: pale yellow
• solubility: DMSO: >5 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1ccc(CCn2nnnc2C3(CC3)c4ccc(C)cc4)cc1
• InChI: 1S/C20H22N4O/c1-15-3-7-17(8-4-15)20(12-13-20)19-21-22-23-24(19)14-11-16-5-9-18(25-2)10-6-16/h3-10H,11-14H2,1-2H3
• InChI key: VREPWWBWXVLSEF-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Mephetyl tetrazole is a potent and selective K_v1.5 potassium channel blocker.

Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC₅₀ = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)