N3538

Nateglinid

≥98% (HPLC), solid

• Synonym(e): N-[(trans-4-Isopropylcyclohexyl)-carbonyl]-D-phenylalanin, Fastic, Starlix, Starsis
• Empirische Formel (Hill-System): C₁₉H₂₇NO₃
• CAS-Nummer: 105816-04-4
• Molekulargewicht: 317.42
• NACRES: NA.77
• PubChem Substance ID: 329818636
• UNSPSC Code: 12352200
• MDL number: MFCD00875706
• eCl@ss: 32150313
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• solubility: DMSO: >5 mg/mL, H₂O: insoluble
• originator: Novartis
• storage temp.: room temp
• SMILES string: CC(C)[C@@H]1CC[C@H](CC1)C(=O)N[C@H](Cc2ccccc2)C(O)=O
• InChI: 1S/C19H27NO3/c1-13(2)15-8-10-16(11-9-15)18(21)20-17(19(22)23)12-14-6-4-3-5-7-14/h3-7,13,15-17H,8-12H2,1-2H3,(H,20,21)(H,22,23)/t15-,16-,17-/m1/s1
• InChI key: OELFLUMRDSZNSF-BRWVUGGUSA-N
• Gene Information: human ... ABCC8(6833), KCNJ11(3767)

Beschreibung

Biochem/physiol Actions

Nateglinide is a short-acting insulin secretagogue useful in treating type 2 diabetes. It is an insulinotropic agent effective for postprandial hyperglycemia. Nateglinide restores prandial insulin levels in a glucose-dependent manner.

Nateglinid ist ein K_ir6.2/SUR1 Kanal-Hemmer und Antidiabetikum

Nateglinide is a Kir6.2/SUR1 channel inhibitor and antidiabetic. It is selective for the SUR1 subtype, which is found on pancreatic islet cells. Nateglinide evokes KATP channel-dependent insulin secretion (50-200 μM) in the absence and presence of insulin.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)