N4663

Anti-Nurr1 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-NOT, Anti-NR4A2, Anti-Nuclear receptor of T cells, Anti-TINUR
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD02263849
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC, WB
• Citations: 6

Eigenschaften

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: mouse, rat, human
• concentration: ~1 mg/mL
• technique(s): immunohistochemistry: 1:100-1:200, western blot: 1:1,000-1:2,000
• UniProt accession no.: F1D8N6
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... NR4A2(4929) ; mouse ... Pls3(18827) ; rat ... Nr4a2(54278)

Beschreibung

General description

Nur-related factor 1 (Nurr1) belongs to nuclear receptor super family. It is a brain-specific transcription factor, confined to central nervous system. Additionally, Nurr1 also modulates gene expression by repressing other transcriptional factors. Nurr1 is expressed in developing and mature dopamine neurons, hippocampus and cerebral cortex. It is crucial for the early development of dopamine neurons in midbrain during development, protection and survival of the neurons. Nurr1 may play a very critical role in the development of Parkinson′s disease and other neurodegenerative diseases and in human atherosclerotic lesions
Anti- Nurr1 recognizes human Nurr1.

Immunogen

synthetic peptide corresponding to an internal sequence of human Nurr1.

Application

Anti-Nurr 1 antibody may be used in immunoblotting at a working dilution of 1:1000 to 1:2000. For immunohistochemistry the recommended dilution is 1:100 to 1:200.

Physical form

Solution in phosphate buffered saline, containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)