O0886

Olomoucine

Name: Olomoucine
Brand: SIGMA
Price: 86.2 EUR

≥98% (HPLC)

Synonym(e):

2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine

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1 MG

€ 86,20

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€ 235,00

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₅H₁₈N₆O

CAS-Nummer:

101622-51-9

Molekulargewicht:

298.34

NACRES:

NA.77

PubChem Substance ID:

24278053

UNSPSC Code:

12352200

MDL number:

MFCD00189360

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Produktname

Olomoucine, ≥98% (HPLC)

InChI

1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)

SMILES string

Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12

InChI key

GTVPOLSIJWJJNY-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

solubility

DMSO: 20 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

100

Gene Information

human ... CDC2(983), CDK2(1017), CDK3(1018), CDK4(1019), CDK5(1020), CDK6(1021), CDK7(1022), CDK8(1024), CDK9(1025), CDKN1A(1026), CDKN1B(1027), CDKN1C(1028), CDKN2A(1029), CDKN2B(1030), CDKN2C(1031), CDKN2D(1032), CDKN3(1033)
rat ... Prkca(24680)

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Dieser Artikel	SML1482	SML0868	SML1464
Sigma-Aldrich O0886 Olomoucine	Sigma-Aldrich SML1482 Ogerin	Sigma-Aldrich SML0868 Purmorphamine	Sigma-Aldrich SML1464 SMBA1
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C
solubility DMSO: 20 mg/mL, clear, colorless	solubility DMSO: 25 mg/mL, clear	solubility DMSO: 5 mg/mL, clear (warmed)	solubility DMSO: 20 mg/mL, clear
Gene Information human ... CDC2(983), CDK2(1017), CDK3(1018), CDK4(1019), CDK5(1020), CDK6(1021), CDK7(1022), CDK8(1024), CDK9(1025), CDKN1A(1026), CDKN1B(1027), CDKN1C(1028), CDKN2A(1029), CDKN2B(1030), CDKN2C(1031), CDKN2D(1032), CDKN3(1033) rat ... Prkca(24680)	Gene Information -	Gene Information -	Gene Information -

Biochem/physiol Actions

Olomoucine is a purine derivative which inhibits cyclin-dependent kinases and induces G arrest.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases.

R T Abraham et al.

Biology of the cell, 83(2-3), 105-120 (1995-01-01)

Olomoucine (2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine) has been recently described as a competitive inhibitor (ATP-binding site) of the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cyclin A and p33cdk2/cyclin E kinases, the brain p33cdk5/p35 kinase and the ERK1/MAP-kinase. The unusual specificity of this compound towards cell

Downregulation of gastrokine-1 in gastric cancer tissues and restoration of its expression induced gastric cancer cells to apoptosis.

Wei Mao et al.

Journal of experimental & clinical cancer research : CR, 31, 49-49 (2012-05-25)

Gastrokine-1 (GKN1), a secreted protein, is specifically expressed in gastric mucosa to protect and maintain the integrity of gastric epithelium. The present study investigated differential expression of GKN1 in normal, precancerous, and cancerous gastric tissues, and explored the biological functions

The Cdk5 inhibitor olomoucine promotes corneal debridement wound closure in vivo.

Brajendra K Tripathi et al.

Molecular vision, 14, 542-549 (2008-04-04)

To investigate the effect of the Cdk5 inhibitor olomoucine on corneal debridement wound healing in vivo. Corneal debridement wounds of 1.5 mm were made on the ocular surface of CD-1 mice. A 20 microl drop of 15 microM olomoucine in

Inhibition of cyclin-dependent kinases by purine analogues.

J Veselý et al.

European journal of biochemistry, 224(2), 771-786 (1994-09-01)

While testing purines related to the non-specific protein kinase inhibitors N6-dimethylaminopurine and N6-(delta 2-isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discovered a compound with high specificity, 2-(2-hydroxyethylamino)-6- benzylamino-9-methylpurine (olomoucine). Kinetic analysis of kinase inhibition reveals that olomoucine

Steering neuronal growth cones by shifting the imbalance between exocytosis and endocytosis.

Takuro Tojima et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(21), 7165-7178 (2014-05-23)

Extracellular molecular cues guide migrating growth cones along specific routes during development of axon tracts. Such processes rely on asymmetric elevation of cytosolic Ca(2+) concentrations across the growth cone that mediates its attractive or repulsive turning toward or away from

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Olomoucine