P0865

N-(3-Pyridyl)indomethacinamide

≥98%

• Synonym(e): N-(3-Pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide, N-3PyIA
• Empirische Formel (Hill-System): C₂₄H₂₀N₃O₃Cl
• CAS-Nummer: 261766-29-4
• Molekulargewicht: 433.89
• NACRES: NA.77
• PubChem Substance ID: 329820062
• UNSPSC Code: 12352200
• MDL number: MFCD02683393

Eigenschaften

• Quality Segment: 200
• assay: ≥98%
• form: powder
• solubility: chloroform: 10 mg/mL to clear, colorless to light yellow
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: COc1ccc2n(c(C)c(CC(=O)Nc3cccnc3)c2c1)C(=O)c4ccc(Cl)cc4
• InChI: 1S/C24H20ClN3O3/c1-15-20(13-23(29)27-18-4-3-11-26-14-18)21-12-19(31-2)9-10-22(21)28(15)24(30)16-5-7-17(25)8-6-16/h3-12,14H,13H2,1-2H3,(H,27,29)
• InChI key: DTAPHQYAZUTCIG-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Potent and selective reversible cyclooxygenase-2 (COX-2) inhibitor (IC₅₀ = 0.1 μM, human recombinant); about 300-fold less potent as an inhibitor of human recombinant COX-1. Not as selective with natural ovine COX (IC₅₀ = 75 μM for COX-1 and 50 μM for COX-2).

Potent and selective reversible cyclooxygenase-2 (COX-2) inhibitor. Not as selective with natural ovine COX.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)