P4532

(−)-N⁶-(2-Phenylisopropyl)adenosine

solid

• Synonym(e): (R)-N⁶-(1-Methyl-2-phenylethyl)adenosine, N⁶-(L-2-Phenylisopropyl)adenosine, R-(−)-PIA
• Empirische Formel (Hill-System): C₁₉H₂₃N₅O₄
• CAS-Nummer: 38594-96-6
• Molekulargewicht: 385.42
• NACRES: NA.77
• PubChem Substance ID: 24277681
• UNSPSC Code: 12352200
• EC Number: 254-028-5
• MDL number: MFCD00069194
• Form: solid

Eigenschaften

• form: solid
• Quality Segment: 200
• potency: 1.17 nM K_i for A₁ receptors (using [³H]CHA in rat forebrain preparations)
• color: white
• solubility: H₂O: slightly soluble 0.3 mg/mL (Solutions may be stored for several days at 4°C.), 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL (Solutions may be stored for several days at 4°C.)
• storage temp.: 2-8°C
• SMILES string: C[C@H](Cc1ccccc1)Nc2ncnc3n(cnc23)[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O
• InChI: 1S/C19H23N5O4/c1-11(7-12-5-3-2-4-6-12)23-17-14-18(21-9-20-17)24(10-22-14)19-16(27)15(26)13(8-25)28-19/h2-6,9-11,13,15-16,19,25-27H,7-8H2,1H3,(H,20,21,23)/t11-,13-,15-,16-,19-/m1/s1
• InChI key: RIRGCFBBHQEQQH-SSFGXONLSA-N
• Gene Information: human ... ADORA1(134)

Beschreibung

Biochem/physiol Actions

A₁ adenosine receptor agonist. Affinity for adenosine receptor is approx. 100× that of the (+)-isomer.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)