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S1071

α-Synuclein A53T human

recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder

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Größe/SKUVerfügbarkeitPreis
500 μg
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€ 789,00

Über diesen Artikel

UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:

€ 789,00


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recombinant

expressed in E. coli

Quality Segment

assay

≥90% (SDS-PAGE)

form

lyophilized powder

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... SNCA(6622)

General description

α-Synuclein is mapped to human chromosome 4q22.1. It is an intrinsically disordered protein with N-terminal imperfect repeats (KTKEGV), a central NAC crucial for aggregation and an acidic rich flexible C-terminal region.α-Synuclein is present in the Lewy bodies (LBs) and Lewy neurites (LNs).

Application

α-Synuclein A53T human has been used to treat mesencephalic neuronal and stimulate microglial cells prior to reactive oxygen species (ROS) measurement, immunohistochemistry and imaging studies.

Biochem/physiol Actions

α-Synuclein (α-Syn) interacts with toll-like receptor 2 (TLR2) and mediates interleukin-1β (IL-1β) synthesis.
A point mutation in the α-synuclein gene, A53T (Ala53-Thr), is linked to familial Parkinson′s disease.
A point mutation in the α-synuclein gene, A53T (Ala53-Thr), is linked to familial Parkinson′s disease. Mice expressing A53T human α-synuclein, but not wild-type or the A30P variants, develop adult-onset neurodegenerative disease with a progressive motoric dysfunction leading to death.

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Dieser Artikel
S7820AB5038MABN826
description

recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder

description

recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder

description

serum, Chemicon®

description

clone 81A, from mouse

assay

≥90% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

assay

-

assay

-

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

-

recombinant

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

form

lyophilized powder

form

lyophilized powder

form

-

form

-

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

-


Lagerklasse

11 - Combustible Solids

Was ist los?

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

PSA (Persönliche Schutzausrüstung)

Eyeshields, Gloves, type N95 (US)



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Questions

  1. what is it molecular weight?

    1 answer
    1. This material includes a proprietary 20 amino acids tag before the first Met. The calculated molecular weight is not available. However, in SDS-PAGE gels, this product runs at approximately 15 - 20 kDa as shown below.

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