S2194

Anti-SNAP-23 (TS-19) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(e): Anti-Synaptosomal-Associated Protein 23
• UNSPSC Code: 12352203
• MDL number: MFCD05665256
• eCl@ss: 32150313
• Conjugate: unconjugated
• Clone: polyclonal
• Application: ARR, IF, WB
• Citations: 9

Eigenschaften

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 23 kDa
• species reactivity: mouse, rat
• technique(s): indirect immunofluorescence: 1:200 using mouse embryonic 3T3-LT cell line., microarray: suitable, western blot: 1:1,000 using whole cell extract of mouse fibroblasts NIH3T3 cell
• UniProt accession no.: O09044
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SNAP23(8773) ; mouse ... Snap23(20619) ; rat ... Snap23(64630)

Beschreibung

General description

Anti-SNAP-23 (TS-19) is developed in rabbit using a synthetic peptide corresponding to amino acids, located at the C-terminus, of mouse SNAP-23, conjugated to keyhole limpet hemocyanin (KLH) as immunogen. SNARE proteins are present on both vesicle membranes (vesicle SNAREs or vSNAREs) and on target membranes (target SNAREs or t-SNAREs). SNAP-23 (synaptosomal associated protein, 23 kDa, syndet), is a nonneuronal homolog of SNAP-25, originally identified in a human B-lymphocyte cDNA library in a yeast two-hybrid screen for proteins interacting with syntaxin. SNAP-23 is ubiquitously expressed.

Immunogen

synthetic peptide corresponding to amino acids 203-221 located at the C-terminus of mouse SNAP-23, conjugated to KLH. This sequence is identical in rat and highly conserved (84% identity) in human SNAP-23.

Application

Anti-SNAP-23 (TS-19) antibody produced in rabbit has been used in:

• immunofluorescence
• immunoblotting
• immunoprecipitation

Biochem/physiol Actions

SNAP-23 (synaptosomal associated protein, 23 kDa, syndet) is thought to be a key player in many distinct protein trafficking events in non-neuronal cells. For example, SNAP-23 is involved in diverse protein trafficking events such as glucose transporter type 4 (GLUT-4) trafficking in adipocytes, compound exocytosis in mast cells, polarized protein trafficking, platelet dense core granule release.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable