S7323

14-3-3 Sigma histidine-tagged human

recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(e): 14-3-3σ, Epitheliial cell marker protein 1, HME1, Makorin, ring finger protein 3, Mkrn3, Mmel, SFN, Stratifin, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide, YWHAS
• NACRES: NA.32
• UNSPSC Code: 12352202
• eCl@ss: 32160701

Eigenschaften

• recombinant: expressed in E. coli
• assay: ≥90% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• mol wt: ~30 kDa (14-3-3 proteins)
• UniProt accession no.: P31947
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... SFN(2810)

Beschreibung

Biochem/physiol Actions

14-3-3 proteins are involved in a multitude of biological processes and play a regulatory role in processes such as apoptotic cell death, mitogenic signal transduction, and cell cycle control. 14-3-3σ proteins play a critical role in signal transduction pathways and cell cycle regulation. 14-3-3σ is the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to γ-irradiation and other DNA-damaging agents. 14-3-3σ is a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5′ CpG islands in epithelial tumor cells.

Physical form

Supplied as a 0.2 μm filtered solution in 50 mM Tris-HCl, pH 7.6, 1 mM EDTA, 1 mM DTT, and 20% glycerol (w/v).

Sicherheitshinweise

• Lagerklasse: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)