S8071

Salvinorin A

≥98% (HPLC), solid

• Synonym(e): (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(3-furanyl)dodechydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
• Empirische Formel (Hill-System): C₂₃H₂₈O₈
• CAS-Nummer: 83729-01-5
• Molekulargewicht: 432.46
• NACRES: NA.77
• PubChem Substance ID: 24899776
• UNSPSC Code: 12352200
• MDL number: MFCD05664742
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• drug control: regulated under CDSA - not available from Sigma-Aldrich Canada; Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet
• storage condition: protect from light
• color: white
• solubility: DMSO: ≥10 mg/mL, ethanol: ~3 mg/mL
• storage temp.: −20°C
• SMILES string: [H][C@@]12CC[C@@]3(C)[C@@H](C[C@H](OC(C)=O)C(=O)[C@]3([H])[C@@]1(C)C[C@H](OC2=O)c4ccoc4)C(=O)OC
• InChI: 1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1
• InChI key: OBSYBRPAKCASQB-AGQYDFLVSA-N
• Gene Information: human ... OPRD1(4985), OPRK1(4986), OPRM1(4988) ; rat ... Oprk1(29335)

Beschreibung

Application

Salvinorin A was administered to rats to study effects on lactic acid-stimulated stretching.¹

Biochem/physiol Actions

Salvanorin A is a non-nitrogenous κ opioid receptor agonist.

Salvinorin A is a potent, non-nitrogenous κ opioid selective receptor agonist. Salvinorin A is isolated from Salvia divinorum. Salvinorin A displays high affinity at both native (K_i=4.3 nm) and cloned (K_i=16 nm) κ -opioid receptors. Preliminary studies suggest that Salvanorin A is chemically unique among the psychtropic drugs and does not bind to any known receptor.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)