SML0076

Zoniporide hydrochloride hydrate

≥98% (HPLC), sodium-hydrogen exchanger isoform 1 (NHE-1) inhibitor, powder

• Synonym(e): N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide hydrochloride hydrate
• Empirische Formel (Hill-System): C₁₇H₁₆N₆O · xHCl · yH₂O
• CAS-Nummer: 241800-98-6
• Molekulargewicht: 320.35 (anhydrous free base basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825138
• NACRES: NA.77
• MDL number: MFCD04113213
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: Zoniporide hydrochloride hydrate, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: H₂O: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: O.Cl.NC(=N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C4CC4
• InChI: 1S/C17H16N6O.ClH.H2O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H;1H2
• InChI key: UCIJUEGJEFJRMP-UHFFFAOYSA-N

Beschreibung

Application

Zoniporide hydrochloride hydrate may be used in Na⁺/H⁺-mediated cell signaling studies.

Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication.

Biochem/physiol Actions

Potent and selective inhibitor of Na⁺/H⁺ exchanger isoform 1 (NHE-1)

Zoniporide is a potent and selective inhibitor of Na⁺/H⁺ exchanger isoform 1 (NHE-1). IC₅₀ = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na⁺ update with IC₅₀ of 14 nM.

Zoniporide, a selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE-1) has cardioprotective effects against myocardial injuries and ischemic insults. It inhibits the swelling human platelets and attenuates cardiac contractile dysfunction in rats. Zoniporide might have neurotoxic effects as it causes peripheral sensory axonopathy.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable