SML0294

ABL127

≥98% (HPLC)

• Synonym(e): (3R)-1,2-Dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine 1,2-dimethyl ester, (3R)-Dimethyl 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylate, CID24856225
• Empirische Formel (Hill-System): C₁₇H₂₀N₂O₅
• CAS-Nummer: 1073529-41-5
• Molekulargewicht: 332.35
• NACRES: NA.77
• PubChem Substance ID: 329825301
• UNSPSC Code: 12352200
• MDL number: MFCD28053514
• Assay: ≥98% (HPLC)
• Form: film

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: film
• color: colorless
• solubility: DMSO: ≥5 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C1[C@](C2=CC=CC=C2)(C3CCCC3)N(C(OC)=O)N1C(OC)=O
• InChI: 1S/C17H20N2O5/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12/h3-5,8-9,13H,6-7,10-11H2,1-2H3/t17-/m0/s1
• InChI key: ZRHWCAFAIHTQKD-KRWDZBQOSA-N

Beschreibung

Biochem/physiol Actions

ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1).

ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). IC50 values were 11.1 nM and 6.4 nM in MDA-MB-231 and HEK 293T cells with no activity detected against >50 other serine hydrolases. PME-1 regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable