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SML0366

Cipamfylline

≥98% (HPLC)

Synonym(e):

8-Amino-1,3-bis(cyclopropylmethyl)-3,9-dihydro-1H-Purine-2,6-dione, BRL 61063

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PackungsgrößeSKUVerfügbarkeitPreis
5 mg
Warenkorb auf Verfügbarkeit prüfen
€ 366,00
€ 311,10

Über diesen Artikel

Empirische Formel (Hill-System):
C13H17N5O2
CAS-Nummer:
Molekulargewicht:
275.31
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:

€ 311,10

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Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Nc1nc2N(CC3CC3)C(=O)N(CC4CC4)C(=O)c2[nH]1

InChI

1S/C13H17N5O2/c14-12-15-9-10(16-12)17(5-7-1-2-7)13(20)18(11(9)19)6-8-3-4-8/h7-8H,1-6H2,(H3,14,15,16)

InChI key

KSPYMJJKQMWWNB-UHFFFAOYSA-N

Biochem/physiol Actions

Cipamfylline is a PDE4 inhibitor that has been shown to cause a cellular redistribution of PDE4A4 into accretion foci, through an association with the ubiquitin scaffolding protein p62.
Cipamfylline is a PDE4 inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Dieser Artikel
SML0422F124SML0819
assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: >10 mg/mL

solubility

DMSO: 5 mg/mL (clear solution)

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 1 mg/mL, clear (warmed)

color

white to beige

color

white to beige

color

white to beige

color

white to beige


Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Artikel

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and/or cGMP. There are 11 different mammalian PDE families.


David S Coombes et al.
Journal of pharmaceutical sciences, 91(7), 1652-1658 (2002-07-13)
We investigated the morphologies of three polymorphs of 1,3-di(cyclopropylmethyl)-8-aminoxanthine, a compound of pharmaceutical importance. We compared the experimental morphologies with those predicted by theoretical methods. We also predicted the elastic constants of the three polymorphs. These results are used to
A M Badger et al.
Circulatory shock, 44(4), 188-195 (1994-12-01)
Three inhibitors of calcium-dependent cyclic adenosine 3'5'-monophosphate (cAMP) dependent phosphodiesterase IV (PDE IV) were evaluated for their effects on lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF) production in vitro and in vivo and for their ability to protect mice from LPS-induced
D R Buckle et al.
Journal of medicinal chemistry, 37(4), 476-485 (1994-02-18)
Alkylation of the selective type IV phosphodiesterase inhibitor, 8-amino-1,3-bis(cyclopropylmethyl)-xanthine (1, BRL 61063), led exclusively to the N-7 substituted derivatives 2-9, which showed varying selectivities for the PDE type IV isoenzyme relative to PDE Va. The 4-methoxybenzyl derivative 6 in particular



Global Trade Item Number

SKUGTIN
SML0366-25MG04061832899640
SML0366-5MG04061832261027

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